Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 10/20 | 0.67 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | FAAH | O00519 | 2/20 | 0.52 |
| ▸ | DRD4 | P21917 | 1/20 | 0.52 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5487639 | 0.92 | HRH3 (0.66) | SIGMAR1HRH3CYP1A2FAAHDRD4 | |
| SCHEMBL27564901 | 0.84 | SIGMAR1 (0.73) | SIGMAR1FAAH | |
| SCHEMBL3602106 | 0.83 | KMT2A (0.71) | SIGMAR1FAAHPKM | |
| SCHEMBL5480169 | 0.82 | SIGMAR1 (0.62) | SIGMAR1FAAHDRD4 | |
| SCHEMBL5475896 | 0.81 | SIGMAR1 (0.58) | SIGMAR1FAAH | |
| SCHEMBL9372748 | 0.81 | SIGMAR1 (1.00) | SIGMAR1HRH3 | |
| SCHEMBL13149475 | 0.81 | NPC1 (0.73) | SIGMAR1DRD4 | |
| SCHEMBL27564818 | 0.80 | SIGMAR1 (0.76) | SIGMAR1FAAH | |
| SCHEMBL1581417 | 0.79 | CYP1A2 (0.52) | SIGMAR1CYP1A2DRD4 | |
| SCHEMBL13149680 | 0.79 | KMT2A (0.74) | SIGMAR1PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1720848-B1 | DERIVATIVES OF ALKYLPIPERAZINE- AND ALKYLHOMOPIPERAZINE- CARBOXYLATES, PREPARATION METHOD THEREOF AND USE OF SAME AS FAAH ENZYME INHIBITORS | SANOFI AVENTIS (FR) | 2007-12-05 | — | — | EP | disclosed |
| EP-1720848-A1 | DERIVATIVES OF ALKYLPIPERAZINE- AND ALKYLHOMOPIPERAZINE- CARBOXYLATES, PREPARATION METHOD THEREOF AND USE OF SAME AS FAAH ENZYME INHIBITORS | Sanofi-Aventis (FR) | 2006-11-15 | — | — | EP | disclosed |
| WO-2005090322-A1 | DERIVATIVES OF ALKYLPIPERAZINE- AND ALKYLHOMOPIPERAZINE- CARBOXYLATES, PREPARATION METHOD THEREOF AND USE OF SAME AS FAAH ENZYME INHIBITORS | SANOFI-AVENTIS (FR) | 2005-09-29 | — | — | WO | disclosed |