Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 11/20 | 0.62 |
| ▸ | FAAH | O00519 | 1/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.52 |
| ▸ | HTR1A | P08908 | 1/20 | 0.52 |
| ▸ | DRD4 | P21917 | 1/20 | 0.52 |
| ▸ | HTR2A | P28223 | 1/20 | 0.52 |
| ▸ | HRH1 | P35367 | 1/20 | 0.52 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5484678 | 0.91 | MEN1 (0.61) | SIGMAR1FAAHCHRM3 | |
| SCHEMBL27564901 | 0.91 | SIGMAR1 (0.73) | SIGMAR1FAAHKDM4EALDH1A1CHRM3 | |
| SCHEMBL5489773 | 0.89 | SIGMAR1 (0.53) | SIGMAR1FAAHHRH1 | |
| SCHEMBL5475896 | 0.87 | SIGMAR1 (0.58) | SIGMAR1FAAHKDM4EALDH1A1 | |
| SCHEMBL5483514 | 0.87 | MEN1 (0.60) | SIGMAR1FAAH | |
| SCHEMBL27564818 | 0.86 | SIGMAR1 (0.76) | SIGMAR1FAAHCHRM3 | |
| SCHEMBL5490036 | 0.82 | MEN1 (0.55) | SIGMAR1FAAHKDM4EALDH1A1DRD4 | |
| SCHEMBL5481589 | 0.82 | SIGMAR1 (0.67) | SIGMAR1FAAHDRD4 | |
| SCHEMBL2235689 | 0.81 | FAAH (0.69) | SIGMAR1FAAHKDM4EALDH1A1 | |
| SCHEMBL2927709 | 0.81 | MEN1 (0.73) | SIGMAR1FAAHCHRM3HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1720848-B1 | DERIVATIVES OF ALKYLPIPERAZINE- AND ALKYLHOMOPIPERAZINE- CARBOXYLATES, PREPARATION METHOD THEREOF AND USE OF SAME AS FAAH ENZYME INHIBITORS | SANOFI AVENTIS (FR) | 2007-12-05 | — | — | EP | claimed |
| EP-1720848-B1 | DERIVATIVES OF ALKYLPIPERAZINE- AND ALKYLHOMOPIPERAZINE- CARBOXYLATES, PREPARATION METHOD THEREOF AND USE OF SAME AS FAAH ENZYME INHIBITORS | SANOFI AVENTIS (FR) | 2007-12-05 | — | — | EP | disclosed |
| EP-1720848-A1 | DERIVATIVES OF ALKYLPIPERAZINE- AND ALKYLHOMOPIPERAZINE- CARBOXYLATES, PREPARATION METHOD THEREOF AND USE OF SAME AS FAAH ENZYME INHIBITORS | Sanofi-Aventis (FR) | 2006-11-15 | — | — | EP | disclosed |
| WO-2005090322-A1 | DERIVATIVES OF ALKYLPIPERAZINE- AND ALKYLHOMOPIPERAZINE- CARBOXYLATES, PREPARATION METHOD THEREOF AND USE OF SAME AS FAAH ENZYME INHIBITORS | SANOFI-AVENTIS (FR) | 2005-09-29 | — | — | WO | disclosed |