Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.66 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.61 |
| ▸ | FAAH | O00519 | 2/20 | 0.57 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.54 |
| ▸ | PKM | P14618 | 1/20 | 0.54 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | DRD4 | P21917 | 1/20 | 0.50 |
| ▸ | MC4R | P32245 | 1/20 | 0.50 |
| ▸ | MC5R | P33032 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5481589 | 0.92 | SIGMAR1 (0.67) | HRH3SLC6A4FAAHSIGMAR1PKM | |
| SCHEMBL3602106 | 0.85 | KMT2A (0.71) | FAAHSIGMAR1KMT2AMEN1PKM | |
| SCHEMBL17444607 | 0.84 | FAAH (0.58) | HRH3FAAHSIGMAR1NPC1CYP1A2 | |
| SCHEMBL14339867 | 0.84 | HRH3 (0.59) | HRH3SLC6A4FAAHSIGMAR1KMT2A | |
| SCHEMBL2927709 | 0.83 | MEN1 (0.73) | FAAHSIGMAR1KMT2AMEN1KCNH2 | |
| SCHEMBL17444603 | 0.82 | KCNH2 (0.52) | HRH3FAAHKMT2AMEN1KCNH2 | |
| SCHEMBL17444604 | 0.81 | HRH3 (0.56) | HRH3SLC6A4FAAHSIGMAR1PKM | |
| SCHEMBL5484678 | 0.81 | MEN1 (0.61) | HRH3FAAHSIGMAR1KMT2AMEN1 | |
| SCHEMBL20612472 | 0.80 | HRH3 (0.76) | HRH3SLC6A4SIGMAR1KMT2APKM | |
| SCHEMBL5477755 | 0.80 | FAAH (0.57) | FAAHSIGMAR1KMT2AMEN1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3169683-A1 | FUNCTIONALISED AND SUBSTITUTED INDOLES AS ANTI-CANCER AGENTS | Novogen Ltd. (AU) | 2017-05-24 | — | — | EP | disclosed |
| WO-2016008011-A1 | FUNCTIONALISED AND SUBSTITUTED INDOLES AS ANTI-CANCER AGENTS | Novogen ltd (AU) | 2016-01-21 | — | — | WO | disclosed |
| EP-1720848-B1 | DERIVATIVES OF ALKYLPIPERAZINE- AND ALKYLHOMOPIPERAZINE- CARBOXYLATES, PREPARATION METHOD THEREOF AND USE OF SAME AS FAAH ENZYME INHIBITORS | SANOFI AVENTIS (FR) | 2007-12-05 | — | — | EP | disclosed |