Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.58 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.50 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | CDK1 | P06493 | 2/20 | 0.49 |
| ▸ | KDR | P35968 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | PLK4 | O00444 | 1/20 | 0.49 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.49 |
| ▸ | AURKA | O14965 | 1/20 | 0.49 |
| ▸ | CHUK | O15111 | 1/20 | 0.49 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.49 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.49 |
| ▸ | INSR | P06213 | 1/20 | 0.49 |
| ▸ | CSF1R | P07333 | 1/20 | 0.49 |
| ▸ | PIM1 | P11309 | 1/20 | 0.49 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.49 |
| ▸ | PRKACA | P17612 | 1/20 | 0.49 |
| ▸ | FLT1 | P17948 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5480719 | 0.80 | KDM4E (0.48) | KDM4EADORA2AADORA1ALDH1A1HTT | |
| SCHEMBL1146649 | 0.75 | BRD4 (0.50) | CDK1KDRKMT2ANPC1RAB9A | |
| SCHEMBL31409720 | 0.74 | KDM4E (0.40) | KDM4EADORA2AADORA1ALDH1A1HTT | |
| SCHEMBL3259926 | 0.73 | ALDH1A1 (0.46) | KDM4EADORA2AADORA1ALDH1A1HTT | |
| SCHEMBL5483517 | 0.72 | ADORA2A (0.60) | KDM4EADORA2AADORA1ALDH1A1HTT | |
| SCHEMBL29588691 | 0.72 | CSNK1A1 (0.40) | KDM4EADORA2AADORA1ALDH1A1HTT | |
| SCHEMBL5030532 | 0.72 | CSNK1A1 (0.40) | KDM4EADORA2AADORA1ALDH1A1HTT | |
| SCHEMBL7092833 | 0.71 | ALDH1A1 (0.65) | KDM4EADORA2AADORA1ALDH1A1HTT | |
| SCHEMBL169815 | 0.71 | CYP11B1 (0.49) | KDM4EADORA2AADORA1ALDH1A1HTT | |
| SCHEMBL5149644 | 0.71 | ALDH1A1 (0.55) | KDM4EADORA2AADORA1ALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070287738-A1 | Substituted Cyanopyridines as protein kinase inhibitors | WYETH | 2007-12-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070287738-A1 | Substituted Cyanopyridines as protein kinase inhibitors | CNKSR1, MAP3K1, MAP3K6 | KDM4E 959/4885ADORA2A 1009/4885ADORA1 671/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.