Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 13/20 | 0.39 |
| ▸ | ACACB | O00763 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.37 |
| ▸ | PIM1 | P11309 | 1/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 8/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.34 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5484802 | 0.87 | ACACB (0.36) | LMNASLC6A4ACACBMAOBAOC3 | |
| SCHEMBL28768495 | 0.80 | ACACB (0.41) | SLC6A4ACACBMAOBAOC3SLC6A3 | |
| SCHEMBL5481366 | 0.80 | PTGS2 (0.39) | SLC6A4ACACBSLC6A3SLC6A2 | |
| SCHEMBL80921 | 0.77 | ACACB (0.46) | LMNAACACBMAOBAOC3HRH3 | |
| SCHEMBL5484157 | 0.75 | POLB (0.42) | LMNASLC6A4ACACBSLC6A3HRH3 | |
| SCHEMBL20552125 | 0.74 | POLB (0.42) | LMNAHRH3 | |
| SCHEMBL16841023 | 0.73 | ACACB (0.44) | LMNASLC6A4ACACBMAOBAOC3 | |
| SCHEMBL20552808 | 0.73 | HRH3 (0.41) | LMNAHRH3 | |
| SCHEMBL3874694 | 0.72 | GABRP (0.44) | LMNAACACBMAOBAOC3HRH3 | |
| SCHEMBL28659226 | 0.71 | ACACB (0.50) | ACACBMAOBAOC3FFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1997619-B | Ethynyl containing phenyl derivatives | HOFFMANN LA ROCHE | 2010-08-25 | — | — | CN | disclosed |
| US-7253192-B2 | Phenyl derivatives comprising an acetylene group | HOFFMANN-LA ROCHE INC. (US) | 2007-08-07 | — | — | US | disclosed |
| CN-1997619-A | Phenyl derivatives comprising an acetylene group | HOFFMANN LA ROCHE (CH) | 2007-07-11 | — | — | CN | disclosed |
| EP-1765760-A1 | PHENYL DERIVATIVES COMPRISING AN ACETYLENE GROUP | F.HOFFMANN-LA ROCHE AG (CH) | 2007-03-28 | — | — | EP | disclosed |
| WO-2006002802-A1 | PHENYL DERIVATIVES COMPRISING AN ACETYLENE GROUP | F. HOFFMANN-LA ROCHE AG (CH) | 2006-01-12 | — | — | WO | disclosed |
| US-20060004091-A1 | Phenyl derivatives comprising an acetylene group | F. HOFFMANN-LA ROCHE AG (CH) | 2006-01-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060004091-A1 | Phenyl derivatives comprising an acetylene group | PPARD, PPARA, PPARG | LMNA 1426/4885SLC6A4 4267/4885ACACB 47/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.