Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 4/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
| ▸ | HTR2B | P41595 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | METAP2 | P50579 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28204079 | 0.90 | LMNA (0.44) | PARP1LMNAMAPTKMT2AMEN1 | |
| SCHEMBL2964481 | 0.87 | PARP1 (0.45) | PARP1LMNAMAPTKMT2AMEN1 | |
| SCHEMBL5701955 | 0.86 | PARP1 (0.45) | PARP1LMNAMAPTKMT2AMEN1 | |
| Hydrochloric Acid SCHEMBL27970367 | 0.84 | PARP1 (0.44) | PARP1LMNAMAPTKMT2AMEN1 | |
| SCHEMBL6469520 | 0.84 | F2R (0.41) | KMT2AMEN1ALDH1A1F2R | |
| SCHEMBL2729495 | 0.84 | PRNP (0.44) | ALDH1A1KDM4EHPGDHSD17B10F2R | |
| SCHEMBL3352032 | 0.81 | PARP1 (0.41) | PARP1LMNAMAPTKMT2AMEN1 | |
| SCHEMBL5685703 | 0.81 | ALDH1A1 (0.42) | PARP1LMNAMAPTKMT2AMEN1 | |
| SCHEMBL4235369 | 0.81 | CXCR5 (0.49) | PARP1LMNAMAPTKMT2AMEN1 | |
| SCHEMBL6637803 | 0.80 | GAA (0.44) | LMNAKMT2AMEN1SLC6A3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1763509-A1 | ALPHA-HELICAL MIMETICS | THE WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH (AU) | 2007-03-21 | — | — | EP | disclosed |
| WO-2006002474-A1 | ALPHA-HELICAL MIMETICS | THE WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH (AU) | 2006-01-12 | — | — | WO | disclosed |