Lonidamine

Lonidamine

SCHEMBL5483035

N#CC(Cl)Cl.O=C(O)c1nn(Cc2ccc(Cl)cc2Cl)c2ccccc12

nearest known ligand 0.83

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 2/20 0.83
CYP3A4 P08684 2/20 0.83
CYP2C9 P11712 2/20 0.83
CYP2D6 P10635 1/20 0.83
TSHR P16473 1/20 0.83
PMP22 Q01453 1/20 0.83
HIF1A Q16665 1/20 0.83
NPSR1 Q6W5P4 1/20 0.83
PTGER4 P35408 3/20 0.45
MAPT P10636 3/20 0.44
LMNA P02545 3/20 0.44
ALDH1A1 P00352 2/20 0.44
ALOX12 P18054 1/20 0.44
NPC1 O15118 1/20 0.44
SLC9A1 P19634 1/20 0.44
MCL1 Q07820 1/20 0.41
KDM4E B2RXH2 1/20 0.41
GLA P06280 1/20 0.41
HPGD P15428 1/20 0.41
PTGER1 P34995 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Lonidamine SCHEMBL29351122 0.91 CYP1A2 (1.00) CYP1A2CYP3A4CYP2C9CYP2D6TSHR
Lonidamine SCHEMBL7134 0.91 CYP1A2 (1.00) CYP1A2CYP3A4CYP2C9CYP2D6TSHR
Lonidamine SCHEMBL29350056 0.91 CYP1A2 (1.00) CYP1A2CYP3A4CYP2C9CYP2D6TSHR
Lonidamine SCHEMBL28075715 0.85 CYP1A2 (0.87) CYP1A2CYP3A4CYP2C9CYP2D6TSHR
Lonidamine SCHEMBL28086501 0.84 CYP1A2 (0.85) CYP1A2CYP3A4CYP2C9CYP2D6TSHR
SCHEMBL14595228 0.84 TSHR (0.73) CYP1A2CYP3A4CYP2C9CYP2D6TSHR
SCHEMBL14584168 0.84 CYP1A2 (0.73) CYP1A2CYP3A4CYP2C9CYP2D6TSHR
SCHEMBL14584132 0.83 CYP1A2 (0.80) CYP1A2CYP3A4CYP2C9CYP2D6TSHR
SCHEMBL14584151 0.82 CYP1A2 (0.82) CYP1A2CYP3A4CYP2C9CYP2D6TSHR
SCHEMBL21121979 0.82 CYP1A2 (0.82) CYP1A2CYP3A4CYP2C9CYP2D6TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2007062198-A1 METHODS TO ACCELERATE THE ISOLATION OF NOVEL CELL STRAINS FROM PLURIPOTENT STEM CELLS AND CELLS OBTAINED THEREBY ADVANCED CELL TECHNOLOGY, INC. (US) 2007-05-31 WO disclosed