Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 1/20 | 0.60 |
| ▸ | NPC1 | O15118 | 6/20 | 0.50 |
| ▸ | RAB9A | P51151 | 6/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.50 |
| ▸ | GAA | P10253 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 5/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.39 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.39 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5485489 | 0.83 | TYK2 (0.48) | NPC1RAB9ASMN1; SMN2KMT2AMEN1 | |
| SCHEMBL23566394 | 0.75 | USP2 (0.68) | USP2NPC1RAB9ASMN1; SMN2GAA | |
| SCHEMBL1885950 | 0.74 | USP2 (0.60) | USP2NPC1RAB9ASMN1; SMN2GAA | |
| SCHEMBL5482260 | 0.73 | THRB (0.52) | SMN1; SMN2ALDH1A1KDM4EHPGDMAPT | |
| SCHEMBL7406453 | 0.72 | MEN1 (0.67) | SMN1; SMN2GAAALDH1A1KMT2AKDM4E | |
| SCHEMBL6989374 | 0.70 | PARP1 (0.50) | KMT2AMEN1L3MBTL1MAPTTDP1 | |
| SCHEMBL2039310 | 0.70 | FFAR1 (0.43) | — | |
| SCHEMBL11887723 | 0.69 | NPC1 (0.64) | USP2NPC1RAB9ASMN1; SMN2GAA | |
| SCHEMBL30572312 | 0.68 | HTR3E (0.59) | SMN1; SMN2ALDH1A1KMT2AKDM4EMEN1 | |
| SCHEMBL2473717 | 0.68 | HTR3E (0.59) | SMN1; SMN2ALDH1A1KMT2AKDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1856031-A1 | 2-ARYLPROPIONIC ACID DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | DOMPE' pha.r.ma s.p.a. (IT) | 2007-11-21 | — | — | EP | claimed |
| WO-2006063999-A1 | 2-ARYLPROPIONIC ACID DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | DOMPE' PHA.R.MA.S.P.A. (IT) | 2006-06-22 | — | — | WO | claimed |
| EP-1856031-A1 | 2-ARYLPROPIONIC ACID DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | DOMPE' pha.r.ma s.p.a. (IT) | 2007-11-21 | — | — | EP | disclosed |
| WO-2006063999-A1 | 2-ARYLPROPIONIC ACID DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | DOMPE' PHA.R.MA.S.P.A. (IT) | 2006-06-22 | — | — | WO | disclosed |