SCHEMBL5483458

SCHEMBL5483458

COc1c(Br)cc([Si](Cl)(Cl)Cl)cc1Br

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA2 P00918 2/20 0.46
CA4 P22748 2/20 0.46
NQO2 P16083 1/20 0.39
MAPT P10636 1/20 0.38
HPGD P15428 1/20 0.38
HSD17B10 Q99714 1/20 0.37
TPMT P51580 1/20 0.36
TSHR P16473 1/20 0.35
APOBEC3A P31941 1/20 0.35
HTT P42858 1/20 0.35
APOBEC3G Q9HC16 1/20 0.35
CA1 P00915 1/20 0.35
CA6 P23280 1/20 0.35
HTR2A P28223 4/20 0.34
TTR P02766 1/20 0.33
INSR P06213 1/20 0.33
IGF1R P08069 1/20 0.33
MEN1 O00255 1/20 0.33
USP2 O75604 1/20 0.33
KMT2A Q03164 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30930936 0.73 CA2 (0.52) CA2CA4NQO2MAPTHPGD
SCHEMBL5482506 0.73 TSHR (0.36) TSHR
SCHEMBL5481495 0.72 ALDH1A1 (0.47) NQO2MAPTHPGDHTTHTR2A
SCHEMBL301662 0.72 HSD17B10 (0.59) CA2CA4NQO2MAPTHPGD
SCHEMBL1119927 0.72 CA2 (0.56) CA2CA4NQO2MAPTHPGD
SCHEMBL22693914 0.71 CA2 (0.50) CA2CA4NQO2MAPTHPGD
SCHEMBL28497803 0.71 CA2 (0.41) CA2CA4NQO2MAPTHPGD
SCHEMBL3683983 0.70 CA2 (0.54) CA2CA4NQO2MAPTHPGD
SCHEMBL28647762 0.69 CA2 (0.75) CA2CA4NQO2MAPTHPGD
SCHEMBL2398559 0.69 CA2 (0.58) CA2CA4NQO2MAPTHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7291747-B2 Silicon compounds and process for preparation thereof CHISSO CORPORATION (JP) 2007-11-06 US disclosed
US-20040143081-A1 Novel silicon compounds and process for preparation thereof JNC CORPORATION (JP) 2004-07-22 US disclosed