Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 20/20 | 0.62 |
| ▸ | F10 | P00742 | 1/20 | 0.52 |
| ▸ | PRSS1 | P07477 | 4/20 | 0.49 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.49 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23461135 | 0.88 | F2 (0.48) | F2F10PRSS1PRSS2PRSS3 | |
| SCHEMBL5855829 | 0.86 | F2 (0.68) | F2F10PRSS1PRSS2PRSS3 | |
| SCHEMBL23474205 | 0.84 | FPR2 (0.46) | F2F10PRSS1PRSS2PRSS3 | |
| SCHEMBL6957416 | 0.83 | F2 (0.70) | F2PRSS1PRSS2PRSS3 | |
| SCHEMBL5478499 | 0.82 | F2 (0.57) | F2F10PRSS1PRSS2PRSS3 | |
| SCHEMBL5856832 | 0.82 | F2 (0.59) | F2F10 | |
| SCHEMBL5855071 | 0.82 | F2 (0.68) | F2PRSS1 | |
| SCHEMBL5487126 | 0.80 | F2 (0.61) | F2F10PRSS1PRSS2PRSS3 | |
| SCHEMBL5475081 | 0.79 | KDM4E (0.47) | F2PRSS1 | |
| SCHEMBL12670271 | 0.77 | F2 (0.39) | F2F10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8541580-B2 | Process for the preparation of pyrazinone thrombin inhibitor and its intermediates | DIAKRON PHARMACEUTICALS, INC. (US) | 2013-09-24 | — | — | US | disclosed |
| US-8541580-B2 | Process for the preparation of pyrazinone thrombin inhibitor and its intermediates | DIAKRON PHARMACEUTICALS, INC. (US) | 2013-09-24 | — | — | US | disclosed |
| WO-2011056806-A1 | PROCESS FOR THE PREPARATION OF PYRAZINONE THROMBIN INHIBITOR AND ITS INTERMEDIATES | DIAKRON PHARMACEUTICALS, INC. (US) | 2011-05-12 | — | — | WO | disclosed |
| US-20110105753-A1 | PROCESS FOR THE PREPARATION OF PYRAZINONE THROMBIN INHIBITOR AND ITS INTERMEDIATES | DIAKRON PHARMACEUTICALS, INC. (US) | 2011-05-05 | — | — | US | disclosed |
| US-20110105753-A1 | PROCESS FOR THE PREPARATION OF PYRAZINONE THROMBIN INHIBITOR AND ITS INTERMEDIATES | DIAKRON PHARMACEUTICALS, INC. (US) | 2011-05-05 | — | — | US | disclosed |
| US-20070099927-A1 | Aminoalkyl-pyrazinones and-pyridones as thrombin inhibitors | SANTHERA PHARMACEUTICALS (SCHWEIZ) GMBH (CH) | 2007-05-03 | — | — | US | disclosed |
| US-7026324-B2 | Thrombin inhibitors | MERCK & CO., INC. (US) | 2006-04-11 | — | — | US | disclosed |
| WO-2005040137-A1 | AMINOALKYL-PYRAZINONES AND -PYRIDONES AS THROMBIN INHIBITORS | SANTHERA PHARMACEUTICALS (SCHWEIZ) GMBH (CH) | 2005-05-06 | — | — | WO | disclosed |
| EP-1526131-A1 | Aminoalkyl-pyrazinones and -pyridones as thrombin inhibitors | Graffinity Pharmaceuticals Aktiengesellschaft (DE) | 2005-04-27 | — | — | EP | disclosed |
| US-20040097730-A1 | Thrombin inhibitors | MERCK & CO., INC. | 2004-05-20 | — | — | US | disclosed |
| EP-1359913-A1 | THROMBIN INHIBITORS | Merck & Co., Inc. (US) | 2003-11-12 | — | — | EP | disclosed |
| WO-2002064140-A1 | THROMBIN INHIBITORS | MERCK & CO., INC. (US) | 2002-08-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040097730-A1 | Thrombin inhibitors | F3, F2, SERPINC1 | F2 2/4885F10 10/4885PRSS1 101/4885 |
| US-20110105753-A1 | PROCESS FOR THE PREPARATION OF PYRAZINONE THROMBIN INHIBITOR AND ITS INTERMEDIATES | TFPI, TFPI2, F2 | F2 3/4885F10 23/4885PRSS1 73/4885 |
| US-20070099927-A1 | Aminoalkyl-pyrazinones and-pyridones as thrombin inhibitors | F2, F12, SERPINC1 | F2 1/4885F10 11/4885PRSS1 67/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.