Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERN1 | O75460 | 10/20 | 0.58 |
| ▸ | TLR2 | O60603 | 1/20 | 0.58 |
| ▸ | TLR1 | Q15399 | 1/20 | 0.58 |
| ▸ | TLR6 | Q9Y2C9 | 1/20 | 0.58 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.37 |
| ▸ | SRC | P12931 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11673199 | 0.83 | ALDH1A1 (0.53) | ERN1TLR2TLR1TLR6MCHR1 | |
| SCHEMBL6565569 | 0.83 | ERN1 (0.66) | ERN1TLR2TLR1TLR6ALDH1A1 | |
| SCHEMBL17828376 | 0.83 | TLR2 (0.44) | ERN1TLR2TLR1TLR6MCHR1 | |
| SCHEMBL18196579 | 0.82 | ERN1 (0.64) | ERN1TLR2TLR1TLR6ALDH1A1 | |
| SCHEMBL17828382 | 0.81 | MCHR1 (0.41) | ERN1TLR2TLR1TLR6MCHR1 | |
| SCHEMBL28228830 | 0.81 | ERN1 (0.62) | ERN1TLR2TLR1TLR6ALDH1A1 | |
| SCHEMBL5588232 | 0.80 | LMNA (0.50) | MCHR1ALDH1A1HPGDCA1CA2 | |
| SCHEMBL19711779 | 0.78 | ERN1 (0.48) | ERN1TLR2TLR1TLR6CA1 | |
| SCHEMBL172818 | 0.77 | ERN1 (0.66) | ERN1TLR2TLR1TLR6ALDH1A1 | |
| SCHEMBL29442477 | 0.77 | ERN1 (0.66) | ERN1TLR2TLR1TLR6ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2007506661-A | — | — | 2007-03-22 | — | — | JP | claimed |
| EP-1638540-A2 | PYRAZOLIDINEDIONE DERIVATIVES AND THEIR USE AS PLATELET AGGREGATION INHIBITORS | Actelion Pharmaceuticals Ltd. (CH) | 2006-03-29 | — | — | EP | claimed |
| WO-2005000281-A2 | PYRAZOLIDINEDIONE DERIVATIVES AND THEIR USE AS PLATELET AGGREGATION INHIBITORS | ACTELION PHARMACEUTICALS LTD. (CH) | 2005-01-06 | — | — | WO | claimed |