SCHEMBL5483954

SCHEMBL5483954

O=C1NC(=S)NC1=O

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5807409 0.79 POLB (0.39)
SCHEMBL5807413 0.79 POLB (0.39)
SCHEMBL17714494 0.77 SIRT2 (0.48)
SCHEMBL6616749 0.77
Hydantoin SCHEMBL5651123 0.74 CRBN (0.39)
SCHEMBL12838822 0.73 GAA (0.45)
SCHEMBL8997540 0.73 KDM4E (0.41)
SCHEMBL10507305 0.71
Thiobarbituric SCHEMBL16027 0.67
SCHEMBL8991935 0.65 LMNA (0.39)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 76 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2020159407-A1 PIGMENT FOR PROTECTIVE ELEMENTS OF MULTI-LAYERED ARTICLES BASED ON SUBSTITUTED NICKEL DITHIOLENE COMPLEXES WITH ASYMMETRICAL LIGANDS Акционерное общество "Гознак" (АО "Гознак") 2020-08-06 WO claimed
US-7265139-B2 RXR activating molecules INCYTE SAN DIEGO INC. (US) 2007-09-04 US claimed
US-7226940-B2 Substituted heterocycles for the treatment of diabetes and other diseases INCYTE SAN DIEGO, INC. (US) 2007-06-05 US claimed
US-20060004059-A1 Substituted heterocycles for the treatment of diabetes and other diseases PFAHL MAGNUS 2006-01-05 US claimed
US-6974826-B2 Imidazolidinedione derivatives for the treatment of diabetes and other diseases INCYTE SAN DIEGO INC. (US) 2005-12-13 US claimed
EP-1593677-A2 Benzylidene-thiazolidinediones and analogues and their use in the treatment of diabetes Incyte San Diego Incorporated (US) 2005-11-09 EP claimed
EP-1377559-A4 RXR ACTIVATING MOLECULES INCYTE SAN DIEGO INC (US) 2005-09-28 EP claimed
US-20050209286-A1 RXR activating molecules PFAHL MAGNUS 2005-09-22 US claimed
EP-1214304-B1 BENZYLIDENE-THIAZOLIDINEDIONES AND ANALOGUES AND THEIR USE IN THE TREATMENT OF DIABETES INCYTE SAN DIEGO INC (US) 2005-08-24 EP claimed
US-20050070581-A1 Imidazolidinedione derivatives for the treatment of diabetes and other diseases INCYTE SAN DIEGO, INC. 2005-03-31 US claimed
EP-1377559-A2 RXR ACTIVATING MOLECULES Maxia Pharmaceuticals, Inc. (US) 2004-01-07 EP claimed
US-20030105333-A1 RXR activating molecules MAXIA PHARMACEUTICALS, INC. 2003-06-05 US claimed
WO-2002072543-A2 RXR ACTIVATING MOLECULES MAXIA PHARMACEUTICALS, INC. (US) 2002-09-19 WO claimed
EP-1214305-A1 BENZYLIDENE-THIAZOLIDINEDIONES AND ANALOGUES AND THEIR USE IN THE TREATMENT OF INFLAMMATION Maxia Pharmaceuticals, Inc. (US) 2002-06-19 EP claimed
EP-1214304-A1 BENZYLIDENE-THIAZOLIDINEDIONES AND ANALOGUES AND THEIR USE IN THE TREATMENT OF DIABETES Maxia Pharmaceuticals, Inc. (US) 2002-06-19 EP claimed
WO-2001016122-A1 BENZYLIDENE-THIAZOLIDINEDIONES AND ANALOGUES AND THEIR USE IN THE TREATMENT OF DIABETES MAXIA PHARMACEUTICALS, INC. (US) 2001-03-08 WO claimed
WO-2001016123-A1 BENZYLIDENE-THIAZOLIDINEDIONES AND ANALOGUES AND THEIR USE IN THE TREATMENT OF INFLAMMATION MAXIA PHARMACEUTICALS, INC. (US) 2001-03-08 WO claimed
US-4256819-A MEROCYANINES EASTMAN KODAK COMPANY (US) 1981-03-17 US claimed
US-4210715-A TETRAZOLIUM COMPOUND AND SENSITIZING DYE KONISHIROKU PHOTO INDUSTRY CO., LTD. (JP) 1980-07-01 US claimed
EP-4387969-A1 SUBSTITUTED 1,2,4-THIADIAZOLYL NICOTINAMIDES, SALTS OR N-OXIDES THEREOF AND THEIR USE AS HERBICIDALLY ACTIVE SUBSTANCES Bayer Aktiengesellschaft (DE) 2024-06-26 EP disclosed
WO-2023213626-A1 USE OF (5S)-3-[3-(3-CHLORO-2-FLUOROPHENOXY)-6-METHYLPYRIDAZIN-4-YL]-5-(2-CHLORO-4-METHYLBENZYL)-5,6-DIHYDRO-4H-1,2,4-OXADIAZINE FOR CONTROLLING UNWANTED MICROORGANISMS BAYER AKTIENGESELLSCHAFT (DE) 2023-11-09 WO disclosed
WO-2023020963-A1 SUBSTITUTED 1,2,4-THIADIAZOLYL NICOTINAMIDES, SALTS OR N-OXIDES THEREOF AND THEIR USE AS HERBICIDALLY ACTIVE SUBSTANCES BAYER AKTIENGESELLSCHAFT (DE) 2023-02-23 WO disclosed
CN-108727270-B Preparation method of 2-thioimidazolidine-4, 5-diketone 南京信息工程大学 2021-04-20 CN disclosed
WO-2020159407-A1 PIGMENT FOR PROTECTIVE ELEMENTS OF MULTI-LAYERED ARTICLES BASED ON SUBSTITUTED NICKEL DITHIOLENE COMPLEXES WITH ASYMMETRICAL LIGANDS Акционерное общество "Гознак" (АО "Гознак") 2020-08-06 WO disclosed
CN-108727270-A A kind of preparation method of 2- thiocarbamoyl imidazoles alkane -4,5- diketone 南京信息工程大学 2018-11-02 CN disclosed
EP-3010889-B1 ARYLSULFIDE AND ARYLSULFOXIDE DERIVATIVES AS ACARICIDES AND INSECTICIDES BAYER CROPSCIENCE AG (DE) 2018-10-03 EP disclosed
US-9981928-B2 Aryl sulfide derivatives and aryl sulfoxide derivatives as acaricides and insecticides BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2018-05-29 US disclosed
US-20160130240-A1 ARYL SULFIDE DERIVATIVES AND ARYL SULFOXIDE DERIVATIVES AS ACARICIDES AND INSECTICIDES BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2016-05-12 US disclosed
EP-3010889-A1 ARYL SULFIDE DERIVATIVES AND ARYL SULFOXIDE DERIVATIVES AS ACARICIDES AND INSECTICIDES Bayer CropScience Aktiengesellschaft (DE) 2016-04-27 EP disclosed
EP-2916652-A1 LIQUID POLYMER SUSPENSIONS Rhodia Operations (FR) 2015-09-16 EP disclosed
WO-2014202505-A1 ARYL SULFIDE DERIVATIVES AND ARYL SULFOXIDE DERIVATIVES AS ACARICIDES AND INSECTICIDES BAYER CROPSCIENCE AG (DE) 2014-12-24 WO disclosed
WO-2014072429-A1 LIQUID POLYMER SUSPENSIONS RHODIA OPERATIONS (FR) 2014-05-15 WO disclosed
EP-2547204-A2 ARYL AND HETARYL SULFONAMIDES AS ACTIVE AGENTS AGAINST ABIOTIC PLANT STRESS Bayer Intellectual Property GmbH (DE) 2013-01-23 EP disclosed
US-7265139-B2 RXR activating molecules INCYTE SAN DIEGO INC. (US) 2007-09-04 US disclosed
US-7265139-B2 RXR activating molecules INCYTE SAN DIEGO INC. (US) 2007-09-04 US disclosed
US-7226940-B2 Substituted heterocycles for the treatment of diabetes and other diseases INCYTE SAN DIEGO, INC. (US) 2007-06-05 US disclosed
US-7153875-B2 Heterocyclic derivatives for the treatment of cancer and other proliferative diseases INCYTE SAN DIEGO (US) 2006-12-26 US disclosed
US-7141596-B2 Inhibitors of proteins that bind phosphorylated molecules INCYTE CORPORATION (US) 2006-11-28 US disclosed
US-7135492-B2 Increases the concentration of high density lipoprotein cholesterol in the blood; dyslipoproteinemia; angina pectoris, myocardial infarction, antiarrhythmia agents, heart failure, kidney failure stroke, peripheral arterial occulsion WYETH (US) 2006-11-14 US disclosed
US-7115620-B2 1,3-disubstituted-2-thioxo-imidazolidine-4,5-diones as potassium channel openers WYETH (US) 2006-10-03 US disclosed
EP-1643993-A2 SUBSTITUTED ISOCHROMAN COMPOUNDS FOR THE TREATMENT OF METABOLIC DISORDERS, CANCER AND OTHER DISEASES Incyte San Diego Incorporated (US) 2006-04-12 EP disclosed
US-20060004059-A1 Substituted heterocycles for the treatment of diabetes and other diseases PFAHL MAGNUS 2006-01-05 US disclosed
US-6974826-B2 Imidazolidinedione derivatives for the treatment of diabetes and other diseases INCYTE SAN DIEGO INC. (US) 2005-12-13 US disclosed
US-20050272778-A1 Inhibitors of proteins that bind phosphorylated molecules INCYTE CORPORATION 2005-12-08 US disclosed
EP-1593677-A2 Benzylidene-thiazolidinediones and analogues and their use in the treatment of diabetes Incyte San Diego Incorporated (US) 2005-11-09 EP disclosed
EP-1377559-A4 RXR ACTIVATING MOLECULES INCYTE SAN DIEGO INC (US) 2005-09-28 EP disclosed
US-20050209286-A1 RXR activating molecules PFAHL MAGNUS 2005-09-22 US disclosed
EP-1385465-A4 HETEROCYCLIC DERIVATIVES FOR THE TREATMENT OF CANCER AND OTHER PROLIFERATIVE DISEASES INCYTE SAN DIEGO INC (US) 2005-09-07 EP disclosed
EP-1214304-B1 BENZYLIDENE-THIAZOLIDINEDIONES AND ANALOGUES AND THEIR USE IN THE TREATMENT OF DIABETES INCYTE SAN DIEGO INC (US) 2005-08-24 EP disclosed
WO-2005035551-A2 INHIBITORS OF PROTEINS THAT BIND PHOSPHORYLATED MOLECULES INCYTE CORPORATION (US) 2005-04-21 WO disclosed
US-20050070581-A1 Imidazolidinedione derivatives for the treatment of diabetes and other diseases INCYTE SAN DIEGO, INC. 2005-03-31 US disclosed
US-20050038098-A1 Substituted dihydronaphthalene and isochroman compounds for the treatment of metabolic disorders, cancer and other diseases INCYTE CORPORATION 2005-02-17 US disclosed
WO-2004093809-A2 SUBSTITUTED ISOCHROMAN COMPOUNDS FOR THE TREATMENT OF METABOLIC DISORDERS, CANCER AND OTHER DISEASES INCYTE SAN DIEGO INCORPORATED (US) 2004-11-04 WO disclosed
US-6765013-B2 ANTIPROLIFERATIVE AGENTS FOR TREATING ADIPOCYTE DIFFERENTIATION, CANCER, OSTEOARTHRITIS, RHEUMATOID ARTHRITIS, CROHN'S DISEASE OR INFLAMMATORY BOWEL DISEASE INCYTE SAN DIEGO 2004-07-20 US disclosed
EP-1385465-A2 HETEROCYCLIC DERIVATIVES FOR THE TREATMENT OF CANCER AND OTHER PROLIFERATIVE DISEASES Incyte San Diego, Inc. (US) 2004-02-04 EP disclosed
EP-1377559-A2 RXR ACTIVATING MOLECULES Maxia Pharmaceuticals, Inc. (US) 2004-01-07 EP disclosed
US-20030153606-A1 Thiazolidinedione derivatives for the treatment of diabetes and other diseases MAXIA PHARMACEUTICALS, INC. 2003-08-14 US disclosed
US-20030119889-A1 1,3-Disubstituted-2- thioxo-imidazolidine-4,5-dione derivatives useful in the treatment of atherosclerosis WYETH 2003-06-26 US disclosed
US-20030119890-A1 1,3-Disubstituted-2-thioxo-imidazolidine-4,5-diones as potassium channel openers WYETH (US) 2003-06-26 US disclosed
US-20030105333-A1 RXR activating molecules MAXIA PHARMACEUTICALS, INC. 2003-06-05 US disclosed
US-6515003-B1 Useful in the treatment of diseases related to lipid and carbohydrate metabolism MAXIA PHARMACEUTICALS, INC. 2003-02-04 US disclosed
US-20020143182-A1 Heterocyclic derivatives for the treatment of cancer and other proliferative diseases INCYTE GENOMICS, INC. 2002-10-03 US disclosed
WO-2002072543-A2 RXR ACTIVATING MOLECULES MAXIA PHARMACEUTICALS, INC. (US) 2002-09-19 WO disclosed
WO-2002072009-A2 HETEROCYCLIC DERIVATIVES FOR THE TREATMENT OF CANCER AND OTHER PROLIFERATIVE DISEASES MAXIA PHARMACEUTICALS, INC. (US) 2002-09-19 WO disclosed
US-6444615-B1 COMPOUNDS EFFECTIVE AS PREEMERGENT AND POSTEMERGENT HERBICIDES DOW AGROSCIENCES LLC 2002-09-03 US disclosed
US-6444615-B1 COMPOUNDS EFFECTIVE AS PREEMERGENT AND POSTEMERGENT HERBICIDES DOW AGROSCIENCES LLC 2002-09-03 US disclosed
EP-1214305-A1 BENZYLIDENE-THIAZOLIDINEDIONES AND ANALOGUES AND THEIR USE IN THE TREATMENT OF INFLAMMATION Maxia Pharmaceuticals, Inc. (US) 2002-06-19 EP disclosed
EP-1214304-A1 BENZYLIDENE-THIAZOLIDINEDIONES AND ANALOGUES AND THEIR USE IN THE TREATMENT OF DIABETES Maxia Pharmaceuticals, Inc. (US) 2002-06-19 EP disclosed
JP-2001354660-A HERBICIDE ROHM & HAAS CO 2001-12-25 JP disclosed
EP-1157991-A3 Herbicidal imidazolidinetrione and thioxo-imidazolidinediones Dow AgroSciences LLC (US) 2001-12-05 EP disclosed
EP-1157991-A2 Herbicidal imidazolidinetrione and thioxo-imidazolidinediones Dow AgroSciences LLC (US) 2001-11-28 EP disclosed
EP-1157991-A2 Herbicidal imidazolidinetrione and thioxo-imidazolidinediones Dow AgroSciences LLC (US) 2001-11-28 EP disclosed
WO-2001016123-A1 BENZYLIDENE-THIAZOLIDINEDIONES AND ANALOGUES AND THEIR USE IN THE TREATMENT OF INFLAMMATION MAXIA PHARMACEUTICALS, INC. (US) 2001-03-08 WO disclosed
WO-2001016122-A1 BENZYLIDENE-THIAZOLIDINEDIONES AND ANALOGUES AND THEIR USE IN THE TREATMENT OF DIABETES MAXIA PHARMACEUTICALS, INC. (US) 2001-03-08 WO disclosed
US-RE30457-E HISTAMINE RECEPTOR ANTAGONISTS SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) 1980-12-23 US disclosed
US-4152453-A HISTAMINE RECEPTOR ANTAGONISTS SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) 1979-05-01 US disclosed
US-4152453-A HISTAMINE RECEPTOR ANTAGONISTS SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) 1979-05-01 US disclosed