Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Metyrapone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 known ✓ | P15538 | 1/20 | 0.97 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.97 |
| ▸ | LMNA | P02545 | 1/20 | 0.97 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.97 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.97 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.97 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | APP | P05067 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.50 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.49 |
| ▸ | F7 | P08709 | 1/20 | 0.49 |
| ▸ | F3 | P13726 | 1/20 | 0.49 |
| ▸ | SARM1 | Q6SZW1 | 1/20 | 0.49 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.49 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.49 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.49 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.49 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Metyrapone SCHEMBL29462551 | 0.98 | TDP1 (1.00) | TDP1LMNACYP1A2CYP3A4CYP11B1 | |
| Metyrapone SCHEMBL637432 | 0.98 | TDP1 (1.00) | TDP1LMNACYP1A2CYP3A4CYP11B1 | |
| Metyrapone SCHEMBL29917903 | 0.98 | TDP1 (1.00) | TDP1LMNACYP1A2CYP3A4CYP11B1 | |
| SCHEMBL12260655 | 0.90 | CYP3A4 (0.84) | TDP1LMNACYP1A2CYP3A4CYP11B1 | |
| Metyrapone SCHEMBL30807826 | 0.88 | LMNA (0.81) | TDP1LMNACYP1A2CYP3A4CYP11B1 | |
| Metyrapone SCHEMBL667561 | 0.88 | LMNA (0.81) | TDP1LMNACYP1A2CYP3A4CYP11B1 | |
| Metyrapone SCHEMBL667560 | 0.88 | LMNA (0.81) | TDP1LMNACYP1A2CYP3A4CYP11B1 | |
| Metyrapone SCHEMBL7020159 | 0.85 | LMNA (0.74) | TDP1LMNACYP1A2CYP3A4CYP11B1 | |
| SCHEMBL31703901 | 0.80 | LMNA (0.69) | TDP1LMNACYP1A2CYP3A4CYP11B1 | |
| SCHEMBL800635 | 0.80 | LMNA (0.69) | TDP1LMNACYP1A2CYP3A4CYP11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007062198-A1 | METHODS TO ACCELERATE THE ISOLATION OF NOVEL CELL STRAINS FROM PLURIPOTENT STEM CELLS AND CELLS OBTAINED THEREBY | ADVANCED CELL TECHNOLOGY, INC. (US) | 2007-05-31 | — | — | WO | disclosed |