Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Metyrapone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 known ✓ | P15538 | 1/20 | 1.00 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 1.00 |
| ▸ | LMNA | P02545 | 1/20 | 1.00 |
| ▸ | CYP1A2 | P05177 | 1/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 1/20 | 1.00 |
| ▸ | CYP11B2 | P19099 | 1/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | APP | P05067 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.52 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.52 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | F7 | P08709 | 1/20 | 0.50 |
| ▸ | F3 | P13726 | 1/20 | 0.50 |
| ▸ | SARM1 | Q6SZW1 | 1/20 | 0.50 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.50 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.50 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.50 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.50 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Metyrapone SCHEMBL29917903 | 1.00 | TDP1 (1.00) | TDP1LMNACYP1A2CYP3A4CYP11B1 | |
| Metyrapone SCHEMBL29462551 | 1.00 | TDP1 (1.00) | TDP1LMNACYP1A2CYP3A4CYP11B1 | |
| Metyrapone SCHEMBL5484012 | 0.98 | TDP1 (0.97) | TDP1LMNACYP1A2CYP3A4CYP11B1 | |
| SCHEMBL12260655 | 0.92 | CYP3A4 (0.84) | TDP1LMNACYP1A2CYP3A4CYP11B1 | |
| Metyrapone SCHEMBL667560 | 0.90 | LMNA (0.81) | TDP1LMNACYP1A2CYP3A4CYP11B1 | |
| Metyrapone SCHEMBL667561 | 0.90 | LMNA (0.81) | TDP1LMNACYP1A2CYP3A4CYP11B1 | |
| Metyrapone SCHEMBL30807826 | 0.90 | LMNA (0.81) | TDP1LMNACYP1A2CYP3A4CYP11B1 | |
| Metyrapone SCHEMBL7020159 | 0.86 | LMNA (0.74) | TDP1LMNACYP1A2CYP3A4CYP11B1 | |
| SCHEMBL31703901 | 0.82 | LMNA (0.69) | TDP1LMNACYP1A2CYP3A4CYP11B1 | |
| SCHEMBL800635 | 0.82 | LMNA (0.69) | TDP1LMNACYP1A2CYP3A4CYP11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 3201 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4747611-A1 | OPTICAL ELECTRODE ANALYTE DETECTION SYSTEM AND METHODS OF USE | Vital Biosciences Inc. (CA) | 2026-05-27 | — | — | EP | claimed |
| EP-4691556-A2 | HUMANIZED ANTI-ACTH ANTIBODIES AND USE THEREOF | H. Lundbeck A/S (DK) | 2026-02-11 | — | — | EP | claimed |
| US-20250339483-A1 | EXTRACELLULAR VESICLES FROM MICROALGAE, THEIR BIODISTRIBUTION UPON INTRANASAL ADMINISTRATION, AND USES THEREOF | AGS THERAPEUTICS SAS (FR) | 2025-11-06 | — | — | US | claimed |
| EP-3607942-B1 | MEDICAMENT AND METHOD OF DIAGNOSIS | UNIV SHEFFIELD (GB) | 2025-10-01 | — | — | EP | claimed |
| US-12428475-B2 | Humanized anti-ACTH antibodies and use thereof | H. LUNDBECK A/S (DK) | 2025-09-30 | — | — | US | claimed |
| EP-4608424-A1 | EXTRACELLULAR VESICLES FROM MICROALGAE, THEIR BIODISTRIBUTION UPON INTRANASAL ADMINISTRATION, AND USES THEREOF | AGS Therapeutics SAS (FR) | 2025-09-03 | — | — | EP | claimed |
| WO-2025111482-A1 | COMPLEXING AGENT SALT FORMULATIONS OF PHARMACEUTICAL COMPOUNDS AT LOW STOICHIOMETRIC RATIOS | BEXSON BIOMEDICAL, INC. (US) | 2025-05-30 | — | — | WO | claimed |
| WO-2025090362-A1 | METHODS AND SYSTEMS FOR INDUCING APOPTOSIS OF ADIPOSE CELLS | CRYOSA, INC. (US) | 2025-05-01 | — | — | WO | claimed |
| US-20250134915-A1 | METHODS AND SYSTEMS FOR INDUCING APOPTOSIS OF ADIPOSE CELLS | CRYOSA, INC. | 2025-05-01 | — | — | US | claimed |
| US-20250135004-A1 | METHODS AND SYSTEMS FOR INDUCING APOPTOSIS OF ADIPOSE CELLS | CRYOSA, INC. | 2025-05-01 | — | — | US | claimed |
| WO-1995002703-A1 | LYOPHILIZED LIGAND-RECEPTOR COMPLEXES FOR ASSAYS AND SENSORS | U.S. DRUG TESTING, INC. (US) | 1995-01-26 | — | — | WO | claimed |
| EP-0627009-A1 | NOVEL MACROCYCLIC LACTONES AND A PRODUCTIVE STRAIN THEREOF. | PFIZER (US) | 1994-12-07 | — | — | EP | claimed |
| US-5354654-A | Lyophilized ligand-receptor complexes for assays and sensors | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE NAVY (US) | 1994-10-11 | — | — | US | claimed |
| WO-1993016189-A1 | NOVEL MACROCYCLIC LACTONES AND A PRODUCTIVE STRAIN THEREOF | PFIZER INC. (US) | 1993-08-19 | — | — | WO | claimed |
| US-5016655-A | Cigarette manufacturing process | C.A. BLOCKERS, INC. (US) | 1991-05-21 | — | — | US | claimed |
| EP-0165630-B1 | METHOD OF PREPARING A CHLORINATED, BROMINATED, RADIOBROMINATED, IODINATED AND/OR RADIOIODINATED, AROMATIC OR HETEROAROMATIC COMPOUND, AS WELL AS A KIT FOR PREPARING A DIAGNOSTIC COMPOSITION ON THE BASIS OF THIS COMPOUND | MALLINCKRODT, INC.(a Missouri corporation) (US) | 1989-10-18 | — | — | EP | claimed |
| WO-1989006912-A1 | PROCESS FOR MANUFACTURING CIGARETTES EMPLOYING PRESELECTED ALCOHOLS | BLOCKERS C A INC (US) | 1989-08-10 | — | — | WO | claimed |
| EP-0165630-A2 | Method of preparing a chlorinated, brominated, radiobrominated, iodinated and/or radioiodinated, aromatic or heteroaromatic compound, as well as a kit for preparing a diagnostic composition on the basis of this compound | MALLINCKRODT, INC.(a Missouri corporation) (US) | 1985-12-27 | — | — | EP | claimed |
| US-4557934-A | ALONG WITH A DIOL PYRROLIDONE OR AN AZACYCLOPENTAN-2-ONE | THE PROCTER & GAMBLE COMPANY (US) | 1985-12-10 | — | — | US | claimed |
| US-4490350-A | ADRENAL IMAGING AGENTS | ZOLLE LLSE | 1984-12-25 | — | — | US | claimed |