Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Metyrapone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 known ✓ | P15538 | 1/20 | 0.74 |
| ▸ | LMNA | P02545 | 1/20 | 0.74 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.74 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.74 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.74 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.74 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | APP | P05067 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.40 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Metyrapone SCHEMBL637432 | 0.86 | TDP1 (1.00) | LMNACYP1A2CYP3A4CYP11B1CYP11B2 | |
| Metyrapone SCHEMBL29462551 | 0.86 | TDP1 (1.00) | LMNACYP1A2CYP3A4CYP11B1CYP11B2 | |
| Metyrapone SCHEMBL29917903 | 0.86 | TDP1 (1.00) | LMNACYP1A2CYP3A4CYP11B1CYP11B2 | |
| Metyrapone SCHEMBL5484012 | 0.85 | TDP1 (0.97) | LMNACYP1A2CYP3A4CYP11B1CYP11B2 | |
| SCHEMBL12260655 | 0.82 | CYP3A4 (0.84) | LMNACYP1A2CYP3A4CYP11B1CYP11B2 | |
| Metyrapone SCHEMBL667560 | 0.77 | LMNA (0.81) | LMNACYP1A2CYP3A4CYP11B1CYP11B2 | |
| Metyrapone SCHEMBL667561 | 0.77 | LMNA (0.81) | LMNACYP1A2CYP3A4CYP11B1CYP11B2 | |
| Metyrapone SCHEMBL30807826 | 0.77 | LMNA (0.81) | LMNACYP1A2CYP3A4CYP11B1CYP11B2 | |
| SCHEMBL28905361 | 0.73 | LMNA (0.68) | LMNACYP1A2CYP3A4CYP11B1CYP11B2 | |
| SCHEMBL30176840 | 0.73 | LMNA (0.68) | LMNACYP1A2CYP3A4CYP11B1CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1351651-A2 | MILD COSMETIC COMPOSITION WITH STABILIZED RETINOIDS | UNILEVER PLC (GB) | 2003-10-15 | — | — | EP | disclosed |
| EP-1349538-A2 | SKIN CARE PRODUCT CONTAINING RETINOIDS, RETINOID BOOSTER AND PHYTOESTROGENS IN A DUAL COMPARTMENT PACKAGE | UNILEVER PLC (GB) | 2003-10-08 | — | — | EP | disclosed |
| EP-1349536-A2 | STABLE SKIN CARE COMPOSITIONS CONTAINING A RETINOID AND A RETINOID BOOSTER SYSTEM | UNILEVER PLC (GB) | 2003-10-08 | — | — | EP | disclosed |
| EP-1345568-A2 | STABLE SKIN CONDITIONING COMPOSITIONS CONTAINING RETINOID BOOSTERS | UNILEVER PLC (GB) | 2003-09-24 | — | — | EP | disclosed |
| EP-1345586-A2 | STABLE SKIN CARE PRODUCT CONTAINING A RETINOID AND A RETINOID BOOSTER SYSTEM IN A DUAL COMPARTMENT PACKAGE | UNILEVER PLC (GB) | 2003-09-24 | — | — | EP | disclosed |
| WO-2002053125-A2 | SKIN CARE PRODUCT CONTAINING A RETINOID AND A RETINOID BOOSTER SYSTEM IN A DUAL COMPARTMENT PACKAGE | UNILEVER PLC (GB) | 2002-07-11 | — | — | WO | disclosed |
| WO-2002053108-A2 | SKIN CARE PRODUCT CONTAINING RETINOIDS, RETINOID BOOSTER AND PHYTOESTROGENS IN A DUAL COMPARTMENT PACKAGE | UNILEVER PLC (GB) | 2002-07-11 | — | — | WO | disclosed |
| WO-2002053123-A2 | STABLE SKIN CARE PRODUCT CONTAINING A RETINOID AND A RETINOID BOOSTER SYSTEM IN A DUAL COMPARTMENT PACKAGE | UNILEVER PLC (GB) | 2002-07-11 | — | — | WO | disclosed |
| WO-2002053124-A2 | STABLE SKIN CARE COMPOSITIONS CONTAINING A RETINOID AND A RETINOID BOOSTER SYSTEM | UNILEVER PLC (GB) | 2002-07-11 | — | — | WO | disclosed |
| WO-2002053089-A2 | STABLE SKIN CONDITIONING COMPOSITIONS CONTAINING RETINOID BOOSTERS | UNILEVER PLC (GB) | 2002-07-11 | — | — | WO | disclosed |
| WO-2002041849-A2 | MILD COSMETIC COMPOSITION WITH STABILIZED RETINOIDS | UNILEVER PLC (GB) | 2002-05-30 | — | — | WO | disclosed |