SCHEMBL5484215

SCHEMBL5484215

C=C[SiH](CCl)CCCCCCCCCCCCCCCCCC

nearest known ligand 0.41

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
TSHR P16473 6/20 0.41
ALDH1A1 P00352 2/20 0.40
THRB P10828 1/20 0.36
TDP1 Q9NUW8 1/20 0.32
ZDHHC20 Q5W0Z9 1/20 0.31
ZDHHC2 Q9UIJ5 1/20 0.31
PLA2G1B P04054 1/20 0.31
HSP90AA1 P07900 1/20 0.31
RAD52 P43351 1/20 0.31
ATG4B Q9Y4P1 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5486020 1.00 TSHR (0.41) TSHRALDH1A1THRBTDP1ZDHHC20
SCHEMBL8769542 0.84 TSHR (0.42) TSHRALDH1A1THRBZDHHC20ZDHHC2
SCHEMBL8769516 0.81 TSHR (0.39) TSHRALDH1A1THRB
SCHEMBL5968696 0.78 TSHR (0.41) TSHRALDH1A1THRB
SCHEMBL25382520 0.77 TSHR (0.41) TSHRALDH1A1THRB
SCHEMBL5483740 0.77 DNM1 (0.38) TSHRALDH1A1THRB
SCHEMBL4526824 0.73 TSHR (0.46) TSHRALDH1A1THRBZDHHC20ZDHHC2
SCHEMBL6896851 0.73 TSHR (0.46) TSHRALDH1A1THRBZDHHC20ZDHHC2
SCHEMBL2273402 0.72
SCHEMBL7939368 0.71 TSHR (0.44) TSHRALDH1A1THRBZDHHC20ZDHHC2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1596193-B1 Novel stationary phases for use in high-performance liquid chromatography AGILENT TECHNOLOGIES INC (US) 2007-06-20 EP disclosed
US-20060076296-A1 Novel stationary phases for use in high-performance liquid chromatography AGILENT TECHNOLOGIES, INC. 2006-04-13 US disclosed
EP-1596193-A1 Novel stationary phases for use in high-performance liquid chromatography Agilent Technologies, Inc. (US) 2005-11-16 EP disclosed