Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 2/20 | 0.73 |
| ▸ | PDE4A | P27815 | 1/20 | 0.73 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.73 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.73 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.34 |
| ▸ | REN | P00797 | 2/20 | 0.34 |
| ▸ | MBTPS1 | Q14703 | 4/20 | 0.33 |
| ▸ | F10 | P00742 | 1/20 | 0.33 |
| ▸ | PLAU | P00749 | 1/20 | 0.33 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.33 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5484482 | 0.86 | PDE4D (0.74) | PDE4DPDE4APDE4BPDE4CLTB4R | |
| SCHEMBL1824084 | 0.85 | PDE4D (0.73) | PDE4DPDE4APDE4BPDE4CLTB4R | |
| SCHEMBL4187551 | 0.85 | PDE4D (0.73) | PDE4DPDE4APDE4BPDE4CLTB4R | |
| Pumafentrine SCHEMBL8344522 | 0.85 | PDE4D (1.00) | PDE4DPDE4APDE4BPDE4CLTB4R | |
| Pumafentrine SCHEMBL26718 | 0.85 | PDE4D (1.00) | PDE4DPDE4APDE4BPDE4CLTB4R | |
| SCHEMBL7204721 | 0.85 | PDE4D (1.00) | PDE4DPDE4APDE4BPDE4CLTB4R | |
| SCHEMBL4187035 | 0.85 | PDE4D (0.75) | PDE4DPDE4APDE4BPDE4CLTB4R | |
| Pumafentrine SCHEMBL29651667 | 0.85 | PDE4D (1.00) | PDE4DPDE4APDE4BPDE4CLTB4R | |
| Pumafentrine SCHEMBL447418 | 0.85 | PDE4D (1.00) | PDE4DPDE4APDE4BPDE4CLTB4R | |
| Pumafentrine SCHEMBL5187632 | 0.84 | PDE4D (0.98) | PDE4DPDE4APDE4BPDE4CLTB4R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004067006-A1 | COMBINATION OF A PDE IV INHIBITOR AND A TNF-ALPHA ANTAGONIST | PHARMACIA CORPORATION (US) | 2004-08-12 | — | — | WO | disclosed |