Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Methionine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BHMT known ✓ | Q93088 | 10/20 | 0.38 |
| ▸ | BHMT2 known ✓ | Q9H2M3 | 1/20 | 0.38 |
| ▸ | RNPEP | Q9H4A4 | 1/20 | 0.39 |
| ▸ | NOS2 | P35228 | 2/20 | 0.35 |
| ▸ | NOS3 | P29474 | 1/20 | 0.35 |
| ▸ | NOS1 | P29475 | 1/20 | 0.35 |
| ▸ | ANPEP | P15144 | 1/20 | 0.34 |
| ▸ | ENPEP | Q07075 | 1/20 | 0.34 |
| ▸ | FNTA | P49354 | 2/20 | 0.34 |
| ▸ | FNTB | P49356 | 2/20 | 0.34 |
| ▸ | PGGT1B | P53609 | 1/20 | 0.34 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.33 |
| ▸ | SLC7A11 | Q9UPY5 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | THPO | P40225 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Racemethionine SCHEMBL225189 | 0.93 | BHMT (0.42) | RNPEPBHMTBHMT2NOS2NOS3 | |
| Glycinebetaine SCHEMBL1646002 | 0.90 | PTGS1 (0.41) | ANPEPENPEPPTGS1SLC7A11 | |
| Glycinebetaine SCHEMBL1646004 | 0.90 | PTGS1 (0.41) | ANPEPENPEPPTGS1SLC7A11 | |
| Methionine SCHEMBL1610240 | 0.85 | RNPEP (0.52) | RNPEPBHMTBHMT2NOS2NOS3 | |
| Methionine SCHEMBL12096907 | 0.85 | RNPEP (0.52) | RNPEPBHMTBHMT2NOS2NOS3 | |
| Racemethionine SCHEMBL2418302 | 0.85 | RNPEP (0.52) | RNPEPBHMTBHMT2NOS2NOS3 | |
| Methionine SCHEMBL6045795 | 0.83 | RNPEP (0.50) | RNPEPBHMTBHMT2NOS2NOS3 | |
| Racemethionine SCHEMBL8450224 | 0.81 | PTGS1 (0.55) | RNPEPBHMTBHMT2NOS2NOS3 | |
| Methionine SCHEMBL8450225 | 0.81 | PTGS1 (0.55) | RNPEPBHMTBHMT2NOS2NOS3 | |
| Methionine SCHEMBL7200962 | 0.79 | RNPEP (0.46) | RNPEPBHMTBHMT2NOS2NOS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1583966-A4 | METHODS AND COMPOSITIONS FOR TREATING CARDIOVASCULAR DISEASE USING 1722, 10280, 59917, 85553, 10653, 9235, 21668, 17794, 2210, 6169, 10102, 21061,17662,1468,12282, 6350, 9035,1820, 23652, 7301, 8925, 8701, 3533, 9462, 9123,12788,17729, 65552,1261, 21476, 33770, 9380, 2569654, 33556, 53656, 44143, 32 | MILLENNIUM PHARM INC (US) | 2007-06-27 | — | — | EP | disclosed |
| EP-1583966-A2 | METHODS AND COMPOSITIONS FOR TREATING CARDIOVASCULAR DISEASE USING 1722, 10280, 59917, 85553, 10653, 9235, 21668, 17794, 2210, 6169, 10102, 21061,17662,1468,12282, 6350, 9035,1820, 23652, 7301, 8925, 8701, 3533, 9462, 9123,12788,17729, 65552,1261, 21476, 33770, 9380, 2569654, 33556, 53656, 44143, 32 | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2005-10-12 | — | — | EP | disclosed |
| US-20050037946-A1 | Methods and compositions for treating cardiovascular disease using 1722, 10280, 59917, 85553, 10653, 9235, 21668, 17794, 2210, 6169, 10102, 21061, 17662, 1468, 12282, 6350, 9035, 1820, 23652, 7301, 8925, 8701, 3533, 9462, 9123, 12788, 17729, 65552, 1261, 21476, 33770, 9380, 2569654, 33556, 53656, 44143, 32612, 10671, 261, 44570, 41922, 2552, 2417, 19319, 43969, 8921, 8993, 955, 32345, 966, 1920, 17318, 1510, 14180, 26005, 554, 16408, 42028, 112091, 13886, 13942, 1673, 54946 or 2419 | MILLENNIUM PHARMACEUTICALS, INC. | 2005-02-17 | — | — | US | disclosed |
| WO-2004063340-A2 | METHODS AND COMPOSITIONS FOR TREATING CARDIOVASCULAR DISEASE USING 1722, 10280, 59917, 85553, 10653, 9235, 21668, 17794, 2210, 6169, 10102, 21061,17662,1468,12282, 6350, 9035,1820, 23652, 7301, 8925, 8701, 3533, 9462, 9123,12788,17729, 65552,1261, 21476, 33770, 9380, 2569654, 33556, 53656, 44143, 32612, 10671, 261, 44570, 4 | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2004-07-29 | — | — | WO | disclosed |