Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | CA12 | O43570 | 5/20 | 0.38 |
| ▸ | CA1 | P00915 | 5/20 | 0.38 |
| ▸ | CA9 | Q16790 | 5/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA7 | P43166 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.38 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.38 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7589231 | 0.96 | MEN1 (0.42) | MEN1LMNAMAPTKMT2ASMN1; SMN2 | |
| SCHEMBL20391484 | 0.90 | MEN1 (0.39) | MEN1LMNAMAPTKMT2ASMN1; SMN2 | |
| SCHEMBL13284003 | 0.89 | ACHE (0.48) | MEN1LMNAMAPTKMT2ASMN1; SMN2 | |
| SCHEMBL15432991 | 0.87 | ALDH1A1 (0.42) | MEN1LMNAMAPTKMT2ASMN1; SMN2 | |
| SCHEMBL16141852 | 0.87 | CYP4F2 (0.50) | MEN1LMNAMAPTKMT2ASMN1; SMN2 | |
| SCHEMBL4880814 | 0.87 | KAT6A (0.41) | MEN1LMNAMAPTKMT2ASMN1; SMN2 | |
| SCHEMBL18614954 | 0.84 | MEN1 (0.36) | MEN1LMNAMAPTKMT2ASMN1; SMN2 | |
| SCHEMBL16092464 | 0.83 | GPBAR1 (0.37) | SMN1; SMN2GPBAR1 | |
| SCHEMBL2522114 | 0.81 | KDM4E (0.52) | MEN1LMNAMAPTKMT2ASMN1; SMN2 | |
| SCHEMBL2528507 | 0.79 | NPC1 (0.40) | LMNAMAPTSMN1; SMN2CA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200115339-A1 | EFFLUX-PUMP INHIBITORS AND THERAPEUTIC USES THEREOF | Basilea Pharmaceutica International AG (CH) | 2020-04-16 | — | — | US | disclosed |
| US-10464896-B2 | Efflux-pump inhibitors and therapeutic uses thereof | Basilea Pharmaceutica International AG (CH) | 2019-11-05 | — | — | US | disclosed |
| US-20180179158-A1 | EFFLUX-PUMP INHIBITORS AND THERAPEUTIC USES THEREOF | Basilea Pharmaceutica International AG (CH) | 2018-06-28 | — | — | US | disclosed |
| EP-3307725-A1 | EFFLUX-PUMP INHIBITORS AND THERAPEUTIC USES THEREOF | Basilea Pharmaceutica International AG (CH) | 2018-04-18 | — | — | EP | disclosed |
| CN-107709314-A | Efflux pump inhibitor and its therapeutic use | 巴斯利尔药物国际股份公司 | 2018-02-16 | — | — | CN | disclosed |
| WO-2017042099-A1 | EFFLUX-PUMP INHIBITORS AND THERAPEUTIC USES THEREOF | BASILEA PHARMACEUTICA AG (CH) | 2017-03-16 | — | — | WO | disclosed |
| WO-2016198691-A1 | EFFLUX-PUMP INHIBITORS AND THERAPEUTIC USES THEREOF | BASILEA PHARMACEUTICA AG (CH) | 2016-12-15 | — | — | WO | disclosed |
| US-20070037061-A1 | Polymer electrolyte complex | THE UNIVERSITY OF SHEFFIELD (GB) | 2007-02-15 | — | — | US | disclosed |
| US-20070009805-A1 | Polymer electrolyte | THE UNIVERSITY OF SHEFFIELD (GB) | 2007-01-11 | — | — | US | disclosed |
| WO-2006051323-A1 | POLYMER ELECTROLYTE | THE UNIVERSITY OF SHEFFIELD (GB) | 2006-05-18 | — | — | WO | disclosed |
| EP-1623474-A2 | POLYMER ELECTROLYTE COMPLEX | THE UNIVERSITY OF SHEFFIELD (GB) | 2006-02-08 | — | — | EP | disclosed |
| EP-1623475-A2 | POLYMER ELECTROLYTE COMPLEX | The University Of Sheffield (GB) | 2006-02-08 | — | — | EP | disclosed |
| WO-2004102693-A2 | POLYMER ELECTROLYTE COMPLEX | THE UNIVERSITY OF SHEFFIELD (GB) | 2004-11-25 | — | — | WO | disclosed |
| WO-2004102692-A2 | POLYMER ELECTROLYTE COMPLEX | THE UNIVERSITY OF SHEFFIELD (GB) | 2004-11-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200115339-A1 | EFFLUX-PUMP INHIBITORS AND THERAPEUTIC USES THEREOF | ABCB11, ABCC1, ABCC3 | MEN1 3487/4885LMNA 2385/4885MAPT 3746/4885 |
| US-10464896-B2 | Efflux-pump inhibitors and therapeutic uses thereof | ABCB11, ABCC1, ABCC3 | MEN1 3443/4885LMNA 2482/4885MAPT 3744/4885 |
| US-20180179158-A1 | EFFLUX-PUMP INHIBITORS AND THERAPEUTIC USES THEREOF | ABCB11, ABCC1, ABCC3 | MEN1 3443/4885LMNA 2482/4885MAPT 3744/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.