Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | BRAF | P15056 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.38 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.38 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.38 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.38 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.38 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.38 |
| ▸ | BTK | Q06187 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 3/20 | 0.38 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3114918 | 0.76 | ALDH1A1 (0.42) | ALDH1A1KDM4EGAALMNAHTT | |
| SCHEMBL5485473 | 0.76 | POLB (0.43) | POLBBRAFALDH1A1KDM4EHSD11B1 | |
| SCHEMBL4140382 | 0.70 | MERTK (0.53) | POLBBRAFALDH1A1KDM4EHSD11B1 | |
| SCHEMBL4139629 | 0.70 | MERTK (0.52) | POLBBRAFALDH1A1KDM4EHSD11B1 | |
| SCHEMBL1014624 | 0.70 | HSD11B1 (0.62) | POLBBRAFHSD11B1LMNATSHR | |
| SCHEMBL31364757 | 0.70 | POLB (0.60) | POLBALDH1A1KDM4EHTTTSHR | |
| SCHEMBL15866476 | 0.69 | POLB (0.57) | POLBBRAFALDH1A1KDM4EGAA | |
| SCHEMBL1014425 | 0.69 | HSD11B1 (0.61) | POLBBRAFALDH1A1HSD11B1LMNA | |
| SCHEMBL1015182 | 0.69 | HSD11B1 (0.61) | POLBBRAFALDH1A1HSD11B1LMNA | |
| SCHEMBL27681040 | 0.69 | ALDH1A1 (0.76) | POLBALDH1A1KDM4ELMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1819341-A2 | IL-12 MODULATORY COMPOUNDS | Synta Pharmaceuticals Corporation (US) | 2007-08-22 | — | — | EP | disclosed |
| WO-2006053227-A2 | IL-12 MODULATORY COMPOUNDS | SYNTA PHARMACEUTICALS CORP. (US) | 2006-05-18 | — | — | WO | disclosed |