SCHEMBL548553

SCHEMBL548553

O=Cc1nccc(C(=O)O)c1C=O

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 7/20 0.43
ASPH Q12797 3/20 0.43
KDM8 Q8N371 3/20 0.43
LMNA P02545 2/20 0.40
SMN1; SMN2 Q16637 1/20 0.40
KDM4A O75164 5/20 0.39
L3MBTL1 Q9Y468 3/20 0.39
EGLN1 Q9GZT9 2/20 0.39
HIF1AN Q9NWT6 2/20 0.39
RAB9A P51151 1/20 0.39
TDP1 Q9NUW8 2/20 0.38
ERN1 O75460 1/20 0.37
ALDH1A1 P00352 4/20 0.37
MAPT P10636 3/20 0.37
ALOX15 P16050 2/20 0.37
CYP3A4 P08684 1/20 0.37
TSHR P16473 1/20 0.37
BLM P54132 1/20 0.37
AGER Q15109 1/20 0.37
NPSR1 Q6W5P4 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2221588 0.79 NAPRT (0.52) KDM4EASPHKDM8LMNASMN1; SMN2
SCHEMBL28260878 0.75 KDM4E (0.39) KDM4EASPHKDM8LMNASMN1; SMN2
SCHEMBL30023037 0.74 SMN1; SMN2 (0.60) KDM4ELMNASMN1; SMN2KDM4AL3MBTL1
SCHEMBL1310961 0.74 SMN1; SMN2 (0.60) KDM4ELMNASMN1; SMN2KDM4AL3MBTL1
SCHEMBL28512682 0.72 KDM4E (0.57) KDM4EASPHKDM8LMNASMN1; SMN2
SCHEMBL5423975 0.71 CCR1 (0.48) KDM4ELMNASMN1; SMN2L3MBTL1RAB9A
SCHEMBL730406 0.71 KDM4C (0.49) KDM4EASPHKDM8KDM4AEGLN1
SCHEMBL29951753 0.71 KMO (0.37) KDM4EASPHKDM8LMNASMN1; SMN2
Benzene SCHEMBL28172839 0.70 ALDH1A1 (0.55) KDM4ELMNASMN1; SMN2ALDH1A1MAPT
SCHEMBL11718261 0.70 ALDH1A1 (0.55) KDM4ELMNASMN1; SMN2ALDH1A1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2080750-B1 RADIATION-SENSITIVE COMPOSITION MITSUBISHI GAS CHEMICAL CO (JP) 2020-07-29 EP claimed
CN-108008600-B Radiation-sensitive composition 三菱瓦斯化学株式会社 2021-02-09 CN disclosed
EP-2080750-B1 RADIATION-SENSITIVE COMPOSITION MITSUBISHI GAS CHEMICAL CO (JP) 2020-07-29 EP disclosed
US-9897913-B2 Radiation-sensitive composition MITSUBISHI GAS CHEMICAL COMPANY, INC. (JP) 2018-02-20 US disclosed
US-20150030980-A1 RADIATION-SENSITIVE COMPOSITION MITSUBISHI GAS CHEMICAL CO (JP) 2015-01-29 US disclosed
US-8846292-B2 Radiation-sensitive composition MITSUBISHI GAS CHEMICAL COMPANY, INC. (JP) 2014-09-30 US disclosed
US-20120171379-A1 RADIATION-SENSITIVE COMPOSITION MITSUBISHI GAS CHEMICAL COMPANY, INC. (JP) 2012-07-05 US disclosed
US-8110334-B2 Radiation-sensitive composition MITSUBISHI GAS CHEMICAL COMPANY, INC. (JP) 2012-02-07 US disclosed
US-20100047709-A1 RADIATION-SENSITIVE COMPOSITION MITSUBISHI GAS CHEMICAL COMPANY, INC. (JP) 2010-02-25 US disclosed
EP-2080750-A1 RADIATION-SENSITIVE COMPOSITION Mitsubishi Gas Chemical Company, Inc. (JP) 2009-07-22 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120171379-A1 RADIATION-SENSITIVE COMPOSITION PARG, RAD51, SRMS KDM4E 165/4885ASPH 1858/4885KDM8 858/4885
US-20100047709-A1 RADIATION-SENSITIVE COMPOSITION C1S, C9, RAD51 KDM4E 234/4885ASPH 1004/4885KDM8 705/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.