Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 4/20 | 0.65 |
| ▸ | CA2 | P00918 | 3/20 | 0.65 |
| ▸ | CES2 | O00748 | 2/20 | 0.65 |
| ▸ | CES1 | P23141 | 2/20 | 0.65 |
| ▸ | CA12 | O43570 | 2/20 | 0.59 |
| ▸ | CA4 | P22748 | 1/20 | 0.59 |
| ▸ | CA5A | P35218 | 1/20 | 0.59 |
| ▸ | CA7 | P43166 | 1/20 | 0.59 |
| ▸ | CA9 | Q16790 | 1/20 | 0.59 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.59 |
| ▸ | BCHE | P06276 | 1/20 | 0.49 |
| ▸ | ACHE | P22303 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1901209 | 0.85 | CA1 (0.62) | CA1CA2CES2CES1BCHE | |
| SCHEMBL20819121 | 0.84 | CA2 (0.71) | CA1CA2CA12CA4CA5A | |
| SCHEMBL10405347 | 0.83 | CA1 (0.59) | CA1CA2CES2CES1BCHE | |
| P-Nitrophenylphosphate SCHEMBL2771528 | 0.83 | CA1 (0.86) | CA1CA2CES2CES1BCHE | |
| SCHEMBL548571 | 0.83 | L3MBTL1 (0.63) | CA1CA2CES2CES1CA12 | |
| SCHEMBL233887 | 0.83 | CES2 (0.86) | CA1CA2CES2CES1BCHE | |
| SCHEMBL28574633 | 0.83 | MEN1 (0.53) | CA1CA2CES2CES1CA12 | |
| SCHEMBL21815508 | 0.82 | L3MBTL1 (0.67) | CA1CA2CES2CES1CA12 | |
| SCHEMBL1901207 | 0.82 | CA1 (0.57) | CA1CA2CES2CES1BCHE | |
| SCHEMBL3920864 | 0.81 | CA1 (0.56) | CA1CA2CES2CES1CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 34 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8435964-B2 | Ectonucleotidase pyrophosphate/phosphodiestrase-1 (ENPP-1) as a target for the treatment of aortic valve stenosis and cardiovascular calcification | UNIVERSITE LAVAL (CA) | 2013-05-07 | — | — | US | claimed |
| US-4041111-A | PHOSPHONIC ACID DICHLORIDE REACTED WITH 2-NAPHTHOL OR 4-NITRO-PHENOL, HYDROLYSIS | PURDUE RESEARCH FOUNDATION (US) | 1977-08-09 | — | — | US | claimed |
| US-11999980-B2 | Non-specific nucleases from the genus Pseudomonas for use in facilitating flow of cells through a microfluidic channel | Miltenyi Biotec B.V. & Co. KG (DE) | 2024-06-04 | — | — | US | disclosed |
| EP-3980057-A1 | METHODS OF PRODUCING SHIGA TOXIN B-SUBUNIT (STXB) MONOMERS AND OLIGOMERS, AND USES THEREOF | Institut Curie (FR) | 2022-04-13 | — | — | EP | disclosed |
| US-20210301273-A1 | Non-Specific Nucleases from the Genus Pseudomonas for Use in Facilitating Flow of Cells Through a Microfluidic Channel | Miltenyi Biotec B.V. & Co. KG (DE) | 2021-09-30 | — | — | US | disclosed |
| CN-112996497-A | Morphic forms of complement factor D inhibitors | 艾其林医药公司 | 2021-06-18 | — | — | CN | disclosed |
| EP-3830255-A1 | NON-SPECIFIC NUCLEASES FROM THE GENUS PSEUDOMONAS | Miltenyi Biotec B.V. & Co. KG (DE) | 2021-06-09 | — | — | EP | disclosed |
| WO-2020245321-A1 | METHODS OF PRODUCING SHIGA TOXIN B-SUBUNIT (STxB) MONOMERS AND OLIGOMERS, AND USES THEREOF | INSTITUT CURIE (FR) | 2020-12-10 | — | — | WO | disclosed |
| WO-2020025468-A1 | NON-SPECIFIC NUCLEASES FROM THE GENUS PSEUDOMONAS | Miltenyi Biotec B.V. & Co. KG (DE) | 2020-02-06 | — | — | WO | disclosed |
| US-8545762-B2 | Sensor for detecting compounds | BOARD OF TRUSTEES OF NORTHERN ILLINOIS UNIVERSITY (US) | 2013-10-01 | — | — | US | disclosed |
| US-8435964-B2 | Ectonucleotidase pyrophosphate/phosphodiestrase-1 (ENPP-1) as a target for the treatment of aortic valve stenosis and cardiovascular calcification | UNIVERSITE LAVAL (CA) | 2013-05-07 | — | — | US | disclosed |
| EP-0644932-B1 | PURIFIED FORMS OF DNASE | GENENTECH INC (US) | 2000-08-09 | — | — | EP | disclosed |
| EP-1013284-A2 | Purified forms of dnase | Genentech, Inc. (US) | 2000-06-28 | — | — | EP | disclosed |
| US-5962291-A | MONOCLONAL ANTIBODY CAPABLE OF HYDROLYZING A SUBSTRATE; HAS TWO BINDING SITES: ONE FOR FREE METAL ION, ONE FOR SUBSTRATE | THE REGENTS OF THE UNIVERSITY OF COLORADO (US) | 1999-10-05 | — | — | US | disclosed |
| US-5783433-A | ION EXCHANGING | GENENTECH, INC. (US) | 1998-07-21 | — | — | US | disclosed |
| EP-0644932-A1 | PURIFIED FORMS OF DNASE | GENENTECH, INC. (US) | 1995-03-29 | — | — | EP | disclosed |
| US-5279823-A | Deoxyribonuclease | GENENTECH, INC. (US) | 1994-01-18 | — | — | US | disclosed |
| WO-1993025670-A1 | PURIFIED FORMS OF DNASE | GENENTECH, INC. (US) | 1993-12-23 | — | — | WO | disclosed |
| US-5254801-A | Inducing male sterility for hybrid seed production, cell ablation, counter-negative selection; genetic engineering | MONSANTO COMPANY (US) | 1993-10-19 | — | — | US | disclosed |
| US-4041111-A | PHOSPHONIC ACID DICHLORIDE REACTED WITH 2-NAPHTHOL OR 4-NITRO-PHENOL, HYDROLYSIS | PURDUE RESEARCH FOUNDATION (US) | 1977-08-09 | — | — | US | disclosed |