Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 15/20 | 0.57 |
| ▸ | TP53 | P04637 | 7/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.57 |
| ▸ | MEN1 | O00255 | 4/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.57 |
| ▸ | NPC1 | O15118 | 4/20 | 0.57 |
| ▸ | RAB9A | P51151 | 4/20 | 0.57 |
| ▸ | HTT | P42858 | 3/20 | 0.57 |
| ▸ | LMNA | P02545 | 6/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.49 |
| ▸ | PIP4K2A | P48426 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5472035 | 0.89 | MAPT (0.57) | MAPTTP53KDM4EHSD17B10MEN1 | |
| SCHEMBL5489364 | 0.85 | TRPV1 (0.56) | MAPTTP53KDM4EHSD17B10MEN1 | |
| SCHEMBL14431712 | 0.85 | MAPT (0.53) | MAPTTP53KDM4EHSD17B10MEN1 | |
| SCHEMBL6266860 | 0.81 | MAPT (0.74) | MAPTTP53KDM4EHSD17B10MEN1 | |
| SCHEMBL6265786 | 0.80 | MAPT (0.58) | MAPTTP53KDM4EHSD17B10MEN1 | |
| SCHEMBL6268886 | 0.79 | LMNA (0.73) | MAPTTP53KDM4EMEN1KMT2A | |
| SCHEMBL5470970 | 0.77 | TRPV1 (0.53) | TRPV1ABL1 | |
| SCHEMBL4148677 | 0.75 | TRPV1 (0.54) | TRPV1 | |
| SCHEMBL5490916 | 0.75 | BCDIN3D (0.46) | TRPV1 | |
| SCHEMBL5474863 | 0.74 | MAPT (0.53) | MAPTTP53KDM4EHSD17B10MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070197559-A1 | Aryl substituted purine analogues | NEUROGEN CORPORATION | 2007-08-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070197559-A1 | Aryl substituted purine analogues | ADORA2A, GART, P2RX7 | MAPT 4604/4885TP53 3265/4885KDM4E 3890/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.