Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.36 |
| ▸ | KCNN4 | O15554 | 3/20 | 0.36 |
| ▸ | DPP4 | P27487 | 2/20 | 0.36 |
| ▸ | F2 | P00734 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | SRC | P12931 | 1/20 | 0.32 |
| ▸ | KCNA5 | P22460 | 2/20 | 0.32 |
| ▸ | IDO1 | P14902 | 1/20 | 0.32 |
| ▸ | TDO2 | P48775 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL544573 | 0.74 | TSHR (0.39) | TSHRKCNN4DPP4F2ALDH1A1 | |
| SCHEMBL17931025 | 0.74 | TSHR (0.39) | TSHRKCNN4DPP4F2ALDH1A1 | |
| SCHEMBL23880379 | 0.72 | RIPK1 (0.40) | TSHRDPP4F2HTR2ATAAR1 | |
| SCHEMBL9319014 | 0.70 | KCNN4 (0.48) | TSHRKCNN4DPP4F2ALDH1A1 | |
| SCHEMBL11772008 | 0.70 | KCNN4 (0.48) | TSHRKCNN4DPP4F2ALDH1A1 | |
| SCHEMBL8662376 | 0.70 | TSHR (0.36) | TSHRKCNN4DPP4F2ALDH1A1 | |
| SCHEMBL8755563 | 0.70 | TSHR (0.36) | TSHRKCNN4DPP4F2ALDH1A1 | |
| SCHEMBL1059025 | 0.70 | MAPK1 (0.42) | KCNN4ALDH1A1TAAR1MAPK1 | |
| SCHEMBL1053427 | 0.70 | KCNA5 (0.47) | KCNN4ALDH1A1CYP2D6MAPK1SRC | |
| SCHEMBL1059023 | 0.70 | MAPK1 (0.42) | KCNN4ALDH1A1TAAR1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5607931-A | AMIDES | SCHERING CORPORATION (US) | 1997-03-04 | — | — | US | claimed |
| EP-0662965-A1 | 1,2-DISUBSTITUTED ETHYL AMIDES AS INHIBITORS OF ACAT | SCHERING CORPORATION (US) | 1995-07-19 | — | — | EP | claimed |
| US-5321031-A | Treating cardiovascular disorders | SCHERING CORPORATION (US) | 1994-06-14 | — | — | US | claimed |
| WO-1994006784-A1 | 1,2-DISUBSTITUTED ETHYL AMIDES AS INHIBITORS OF ACAT | SCHERING CORPORATION (US) | 1994-03-31 | — | — | WO | claimed |
| US-7304086-B2 | Inhibitors of glutaminyl cyclase | PROBIODRUG AG (DE) | 2007-12-04 | — | — | US | disclosed |