Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 3/20 | 0.41 |
| ▸ | ADRA2B | P18089 | 3/20 | 0.41 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.41 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.41 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.34 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.34 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.34 |
| ▸ | CES2 | O00748 | 1/20 | 0.32 |
| ▸ | CES1 | P23141 | 1/20 | 0.32 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.31 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.31 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.31 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.31 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2947197 | 1.00 | ADRA2A (0.41) | ADRA2AADRA2BADRA2CADRB1ADRB3 | |
| SCHEMBL22051464 | 0.79 | CES2 (0.35) | ADRA2AADRA2BADRA2CADRB1ADRB3 | |
| SCHEMBL31376555 | 0.79 | SLC18A3 (0.43) | SLC18A3SIGMAR1 | |
| SCHEMBL29811265 | 0.79 | SLC18A3 (0.43) | SLC18A3SIGMAR1 | |
| SCHEMBL4975851 | 0.79 | SLC18A3 (0.43) | SLC18A3SIGMAR1 | |
| SCHEMBL16959073 | 0.79 | GABRA1 (0.31) | ADRA2AADRA2BADRA2CADRB1ADRB3 | |
| SCHEMBL611730 | 0.79 | ADRA2A (0.37) | ADRA2AADRA2BADRA2CADRB1ADRB3 | |
| SCHEMBL14837162 | 0.79 | ADRA2A (0.37) | ADRA2AADRA2BADRA2CADRB1ADRB3 | |
| SCHEMBL30910218 | 0.76 | CES2 (0.33) | ADRA2AADRA2BADRA2CADRB1ADRB3 | |
| SCHEMBL30967943 | 0.76 | HTR2C (0.37) | ADRA2AADRA2BADRA2CADRB1ADRB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1752452-A9 | PROPANE-1,3-DIONE DERIVATIVE OR ITS SALT | Astellas Pharma Inc. (JP) | 2007-12-12 | — | — | EP | disclosed |
| EP-1752452-A1 | PROPANE-1,3-DIONE DERIVATIVE OR ITS SALT | Astellas Pharma Inc. (JP) | 2007-02-14 | — | — | EP | disclosed |