SCHEMBL5486902

SCHEMBL5486902

O=C(Nc1ccccc1)c1cc(C(=O)c2cccc3ccccc23)ccc1O

nearest known ligand 0.63

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16 P62805 1/20 0.63
EP300 Q09472 1/20 0.63
PRMT1 Q99873 1/20 0.63
DEGS1 O15121 1/20 0.57
MEN1 O00255 4/20 0.54
KMT2A Q03164 4/20 0.54
HSD17B10 Q99714 2/20 0.54
KDM4E B2RXH2 1/20 0.54
LMNA P02545 1/20 0.54
TP53 P04637 1/20 0.54
HPGD P15428 1/20 0.54
HTT P42858 1/20 0.54
TMPRSS4 Q9NRS4 1/20 0.53
NPC1 O15118 1/20 0.52
RAB9A P51151 1/20 0.52
NR1H4 Q96RI1 1/20 0.51
ALOX15 P16050 1/20 0.50
TDP1 Q9NUW8 1/20 0.49
POLB P06746 1/20 0.49
F2 P00734 2/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL7207139 0.99 H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16 (0.62) H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16EP300PRMT1DEGS1MEN1
Hydrochloric Acid SCHEMBL7207137 0.97 H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16 (0.60) H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16EP300PRMT1DEGS1MEN1
SCHEMBL14582016 0.86 RXFP1 (0.66) H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16EP300PRMT1TMPRSS4
SCHEMBL14582018 0.86 P2RX1 (0.60) H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16EP300PRMT1DEGS1MEN1
SCHEMBL14582469 0.85 P2RX1 (0.62) H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16EP300PRMT1MEN1KMT2A
SCHEMBL14582006 0.84 SIRT2 (0.58) H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16EP300PRMT1MEN1KMT2A
SCHEMBL5494830 0.81 MCL1 (0.71) H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16EP300PRMT1DEGS1MEN1
SCHEMBL31150345 0.80 DEGS1 (0.78) DEGS1MEN1KMT2AHSD17B10KDM4E
SCHEMBL368228 0.80 DEGS1 (0.78) DEGS1MEN1KMT2AHSD17B10KDM4E
SCHEMBL14582407 0.79 H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16 (0.61) H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16EP300PRMT1DEGS1MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1328507-B1 NAPHTHYLSALICYLANILIDES AS ANTIMICROBIAL AND ANTIINFLAMMATORY AGENTS UNIV NEW YORK STATE RES FOUND (US) 2007-03-14 EP disclosed
CN-1249019-C Naphthylsalicylanilides as antimicrobial and antiinflammatory agents NEW YORK STATE UNIVERSITY RES (US) 2006-04-05 CN disclosed
CN-1468210-A Naphthylsalicylanilides as antimicrobial and antiinflammatory agents ŦԼ������ѧ�о������ 2004-01-14 CN disclosed
EP-1328507-A1 NAPHTHYLSALICYLANILIDES AS ANTIMICROBIAL AND ANTIINFLAMMATORY AGENTS The Research Foundation Of State University of New York (US) 2003-07-23 EP disclosed
US-6407288-B1 AS ANTIBACTERIAL AGAINST GRAM NEGATIVE AND GRAM POSITIVE BACTERIA AND AS ANTIINFLAMMATORY AGENTS THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK 2002-06-18 US disclosed
US-20020065322-A1 NAPHTHYLSALICYLANILIDES AS ANTIMICROBIAL AND ANTIINFLAMMATORY AGENTS RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK, THE 2002-05-30 US disclosed
WO-2002028819-A1 NAPHTHYLSALICYLANILIDES AS ANTIMICROBIAL AND ANTIINFLAMMATORY AGENTS THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK (US) 2002-04-11 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020065322-A1 NAPHTHYLSALICYLANILIDES AS ANTIMICROBIAL AND ANTIINFLAMMATORY AGENTS PTGES3, FPR3, PTGS1 H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16 2346/4885EP300 1501/4885PRMT1 4400/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.