SCHEMBL368228

SCHEMBL368228

O=C(Nc1ccccc1)c1cccc2ccccc12

nearest known ligand 0.78

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
DEGS1 O15121 1/20 0.78
NPC1 O15118 1/20 0.76
RAB9A P51151 1/20 0.76
NR1H4 Q96RI1 1/20 0.72
MEN1 O00255 7/20 0.69
KMT2A Q03164 7/20 0.69
MMP3 P08254 1/20 0.65
HDAC8 Q9BY41 1/20 0.65
PLK1 P53350 1/20 0.62
ALDH1A1 P00352 1/20 0.61
NR4A1 P22736 1/20 0.60
NR4A2 P43354 1/20 0.60
NR4A3 Q92570 1/20 0.60
KDM4E B2RXH2 1/20 0.59
LMNA P02545 1/20 0.59
TP53 P04637 1/20 0.59
HPGD P15428 1/20 0.59
HTT P42858 1/20 0.59
HSD17B10 Q99714 1/20 0.59
CA12 O43570 1/20 0.59

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31150345 1.00 DEGS1 (0.78) DEGS1NPC1RAB9ANR1H4MEN1
SCHEMBL2466597 0.90 MEN1 (0.65) DEGS1NPC1RAB9ANR1H4MEN1
SCHEMBL26889396 0.89 DEGS1 (0.79) DEGS1NPC1RAB9ANR1H4MEN1
SCHEMBL3659132 0.89 DEGS1 (0.72) DEGS1NPC1RAB9ANR1H4MEN1
SCHEMBL7890743 0.88 DEGS1 (1.00) DEGS1NPC1RAB9ANR1H4MEN1
SCHEMBL29519104 0.88 DEGS1 (1.00) DEGS1NPC1RAB9ANR1H4MEN1
SCHEMBL26886081 0.88 ALDH1A1 (0.68) DEGS1NPC1RAB9ANR1H4MEN1
SCHEMBL7835842 0.86 DEGS1 (0.74) DEGS1NPC1RAB9ANR1H4MEN1
SCHEMBL677505 0.86 DEGS1 (0.74) DEGS1NPC1RAB9ANR1H4MEN1
SCHEMBL8556169 0.86 DEGS1 (0.69) DEGS1NPC1RAB9ANR1H4MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 529 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11672747-B2 Process for dyeing keratin materials using a direct dye and an aliphatic ammonium salt, and composition comprising same L'OREAL (FR) 2023-06-13 US claimed
CN-105828882-B Packaging article comprising an envelope and an anhydrous dye composition comprising a direct dye, use thereof and process for dyeing keratin fibres 莱雅公司 2022-09-30 CN claimed
US-20220183944-A1 PROCESS FOR DYEING KERATIN MATERIALS USING A DIRECT DYE AND AN ALIPHATIC AMMONIUM SALT, AND COMPOSITION COMPRISING SAME L'OREAL (FR) 2022-06-16 US claimed
US-11278482-B2 Process for dyeing keratin materials using at least one blue, purple or green dye and at least one disulfide, thiol or protected thiol fluorescent dye L'OREAL (FR) 2022-03-22 US claimed
CN-113784701-A Process for dyeing keratin materials using a direct dye and an unsaturated heterocyclic salt, and composition comprising said direct dye and an unsaturated heterocyclic salt 莱雅公司 2021-12-10 CN claimed
CN-113747879-A Process for dyeing keratin materials using a direct dye and an aliphatic ammonium salt and composition comprising said direct dye and an aliphatic ammonium salt 莱雅公司 2021-12-03 CN claimed
EP-3897561-A1 PROCESS FOR DYEING KERATIN MATERIALS USING A DIRECT DYE AND AN UNSATURATED HETEROCYCLIC SALT, AND COMPOSITION COMPRISING SAME L'OREAL (FR) 2021-10-27 EP claimed
EP-3897554-A1 PROCESS FOR DYEING KERATIN MATERIALS USING A DIRECT DYE AND AN ALIPHATIC AMMONIUM SALT, AND COMPOSITION COMPRISING SAME L'OREAL (FR) 2021-10-27 EP claimed
EP-3558254-B1 PROCESS FOR DYEING KERATIN FIBRES USING AT LEAST ONE PARTICULAR 2- OR 4-AZOPYRIDINIUM DYE AND AT LEAST ONE FLUORESCENT DYE OREAL (FR) 2021-09-22 EP claimed
US-10888510-B2 Process for dyeing keratin fibres using at least one particular 2- or 4-azopyridinium dye and at least one fluorescent dye L'OREAL (FR) 2021-01-12 US claimed
WO-2004112737-A2 TINCTORIAL COMPOSITION COMPRISING AT LEAST ONE DIRECT DYE WITH MIXED CHROMOPHORES L'OREAL (FR) 2004-12-29 WO claimed
WO-2004112738-A1 TINCTORIAL BRIGHTENER COMPOSITION CONTAINING AT LEAST ONE DIRECTLY CATIONIC COLORANT HAVING MIXED CHROMOPHORES L'OREAL (FR) 2004-12-29 WO claimed
EP-1377589-A1 OXAZOLYL-PYRAZOLE DERIVATIVES AS KINASE INHIBITORS Pharmacia Italia S.p.A. (IT) 2004-01-07 EP claimed
WO-2002062804-A1 OXAZOLYL-PYRAZOLE DERIVATIVES AS KINASE INHIBITORS PHARMACIA ITALIA S.P.A. (IT) 2002-08-15 WO claimed
US-6136087-A ONE OR MORE COUPLING COMPONENTS SELECTED FROM THE GROUP CONSISTING OF ACETOACETANILIDES, NAPHTHANILIDES, PYRAZALONES AND BENZAMIDAZOLES BEING BONDED TO THE SULFONATED OR CARBOXYLATED AMINES; ANTIAGGREGATION OF PIGMENT PARTICLES UHLICH COLOR COMPANY, INC. (US) 2000-10-24 US claimed
WO-2000026304-A1 CRYSTAL GROWTH INHIBITOR FOR AZO PIGMENTS UHLICH COLOR COMPANY, INC. (US) 2000-05-11 WO claimed
EP-0577245-B1 Photogenerating azo pigments XEROX CORP (US) 1998-12-02 EP claimed
US-5281503-A Multilayer element with disazo pigments and charge generating layer XEROX CORPORATION (US) 1994-01-25 US claimed
EP-0577245-A1 Photogenerating azo pigments XEROX CORPORATION (US) 1994-01-05 EP claimed
US-4369038-A Transfer-printing paper, its manufacture and uses CIBA-GEIGY LTD. (CH) 1983-01-18 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10888510-B2 Process for dyeing keratin fibres using at least one particular 2- or 4-azopyridinium dye and at least one fluorescent dye KRT18, IK, GLA DEGS1 3983/4885NPC1 4265/4885RAB9A 3128/4885
US-11278482-B2 Process for dyeing keratin materials using at least one blue, purple or green dye and at least one disulfide, thiol or protected thiol fluorescent dye KRT18, IK, CUTA DEGS1 2445/4885NPC1 4379/4885RAB9A 3692/4885
US-11672747-B2 Process for dyeing keratin materials using a direct dye and an aliphatic ammonium salt, and composition comprising same KRT18, MARK1, IK DEGS1 367/4885NPC1 2733/4885RAB9A 3926/4885
US-20220183944-A1 PROCESS FOR DYEING KERATIN MATERIALS USING A DIRECT DYE AND AN ALIPHATIC AMMONIUM SALT, AND COMPOSITION COMPRISING SAME KRT18, MARK1, IK DEGS1 367/4885NPC1 2733/4885RAB9A 3926/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.