Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 6/20 | 0.74 |
| ▸ | CYP19A1 | P11511 | 5/20 | 0.74 |
| ▸ | CYP11B1 | P15538 | 5/20 | 0.74 |
| ▸ | MMP2 | P08253 | 1/20 | 0.64 |
| ▸ | MMP13 | P45452 | 1/20 | 0.64 |
| ▸ | MMP14 | P50281 | 1/20 | 0.64 |
| ▸ | CYP17A1 | P05093 | 3/20 | 0.53 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.53 |
| ▸ | ACHE | P22303 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.50 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5735824 | 0.86 | MKNK1 (0.59) | CYP11B2CYP19A1CYP11B1MMP2MMP13 | |
| SCHEMBL4509922 | 0.85 | CYP11B2 (1.00) | CYP11B2CYP19A1CYP11B1CYP17A1SLC2A1 | |
| SCHEMBL1895643 | 0.81 | CYP2C9 (0.57) | MMP2MMP13MMP14SLC2A1KDM4E | |
| SCHEMBL13712389 | 0.81 | CYP11B2 (0.72) | CYP11B2CYP19A1CYP11B1CYP17A1SLC2A1 | |
| SCHEMBL6041578 | 0.81 | CA12 (0.51) | CYP11B2CYP19A1CYP11B1KDM4EALDH1A1 | |
| SCHEMBL29613178 | 0.81 | CA12 (0.51) | CYP11B2CYP19A1CYP11B1KDM4EALDH1A1 | |
| SCHEMBL23484192 | 0.81 | CA12 (0.56) | CYP11B2CYP19A1CYP11B1MMP2MMP13 | |
| SCHEMBL10028690 | 0.80 | ALDH1A1 (0.56) | MMP2MMP13MMP14SLC2A1KDM4E | |
| SCHEMBL4027305 | 0.79 | MMP2 (0.60) | CYP11B2CYP19A1CYP11B1MMP2MMP13 | |
| SCHEMBL707407 | 0.78 | CA12 (0.67) | SLC2A1KDM4EALDH1A1MAPTCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1853261-A1 | SELECTIVE INHIBITORS OF HUMAN CORTICOSTEROID SYNTHASES | Universität des Saarlandes (DE) | 2007-11-14 | — | — | EP | disclosed |
| WO-2006092430-A1 | SELECTIVE INHIBITORS OF HUMAN CORTICOSTEROID SYNTHASES | Universität des Saarlandes (DE) | 2006-09-08 | — | — | WO | disclosed |