Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 2/20 | 0.40 |
| ▸ | TDO2 | P48775 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | PTGES | O14684 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 2/20 | 0.35 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.35 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.35 |
| ▸ | EGFR | P00533 | 2/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2052409 | 0.78 | TGFBR1 (0.51) | HTR1AADRA1DADRA1AADRA1BNSD3 | |
| SCHEMBL5496607 | 0.75 | GRM4 (0.51) | NPC1RAB9ANPSR1KDM4EMAPT | |
| SCHEMBL757488 | 0.73 | PIK3CA (0.50) | HTR1AADRA1DADRA1AADRA1BNPSR1 | |
| SCHEMBL2047631 | 0.72 | TDO2 (0.47) | IDO1TDO2TGFBR1MAPK14DYRK1A | |
| SCHEMBL373583 | 0.72 | MAPK14 (0.55) | IDO1NPC1RAB9AKDM4ETGFBR1 | |
| SCHEMBL1849077 | 0.71 | NPC1 (0.46) | IDO1TDO2NPC1RAB9AMAPT | |
| SCHEMBL373237 | 0.70 | MAPK14 (0.64) | TDO2EGFRNPSR1LMNAHTT | |
| SCHEMBL5256574 | 0.68 | MAPK14 (0.49) | TGFBR1MAPK14MAP4K4CDK2MAPK9 | |
| SCHEMBL373271 | 0.68 | TGFBR1 (0.59) | IDO1NPC1RAB9AKDM4ETGFBR1 | |
| SCHEMBL5496438 | 0.67 | TGFBR1 (0.56) | TGFBR1MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7276525-B2 | Osteogenesis-promotion enhancer and method of screening the same | NIPPON SHINYAKU CO. LTD. (JP) | 2007-10-02 | — | — | US | disclosed |
| US-20060183778-A1 | Osteogenesis-promotion enhancer and method of screening the same | JAPANESE FOUNDATION OF CANCER RESEARCH (JP) | 2006-08-17 | — | — | US | disclosed |
| EP-1632249-A1 | OSTEOGENESIS-PROMOTION ENHANCER AND METHOD OF SCREENING THE SAME | Nippon Shinyaku Co., Ltd. (JP) | 2006-03-08 | — | — | EP | disclosed |