Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 11/20 | 0.56 |
| ▸ | MAPK14 | Q16539 | 7/20 | 0.56 |
| ▸ | THRB | P10828 | 4/20 | 0.56 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.42 |
| ▸ | AR | P10275 | 1/20 | 0.38 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.38 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.38 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.38 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.38 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.37 |
| ▸ | SOS2 | Q07890 | 1/20 | 0.37 |
| ▸ | GRM5 | P41594 | 1/20 | 0.37 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.37 |
| ▸ | BMP4 | P12644 | 1/20 | 0.36 |
| ▸ | CHKA | P35790 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2044086 | 0.91 | TGFBR1 (0.49) | TGFBR1MAPK14THRBAAK1GABRG2 | |
| SCHEMBL2052409 | 0.89 | TGFBR1 (0.51) | TGFBR1MAPK14THRB | |
| SCHEMBL2042895 | 0.87 | TGFBR1 (0.49) | TGFBR1MAPK14THRBARAAK1 | |
| SCHEMBL376179 | 0.85 | TGFBR1 (0.67) | TGFBR1MAPK14THRB | |
| SCHEMBL2049330 | 0.84 | TGFBR1 (0.59) | TGFBR1MAPK14THRBGRM4 | |
| Fluoromethane SCHEMBL27755992 | 0.83 | TGFBR1 (0.64) | TGFBR1MAPK14THRB | |
| SCHEMBL5488856 | 0.80 | CRHR1 (0.45) | TGFBR1MAPK14THRBGABRG2GABRB3 | |
| SCHEMBL6683670 | 0.79 | TGFBR1 (0.48) | TGFBR1MAPK14THRB | |
| SCHEMBL2045360 | 0.78 | TGFBR1 (0.47) | TGFBR1MAPK14THRBAAK1 | |
| SCHEMBL5907474 | 0.76 | TGFBR1 (0.46) | TGFBR1MAPK14GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7276525-B2 | Osteogenesis-promotion enhancer and method of screening the same | NIPPON SHINYAKU CO. LTD. (JP) | 2007-10-02 | — | — | US | disclosed |
| US-20060183778-A1 | Osteogenesis-promotion enhancer and method of screening the same | JAPANESE FOUNDATION OF CANCER RESEARCH (JP) | 2006-08-17 | — | — | US | disclosed |
| EP-1632249-A1 | OSTEOGENESIS-PROMOTION ENHANCER AND METHOD OF SCREENING THE SAME | Nippon Shinyaku Co., Ltd. (JP) | 2006-03-08 | — | — | EP | disclosed |