Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 7/20 | 0.66 |
| ▸ | DRD2 | P14416 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | RECQL | P46063 | 1/20 | 0.52 |
| ▸ | FAAH | O00519 | 3/20 | 0.52 |
| ▸ | DRD4 | P21917 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5481354 | 0.92 | SIGMAR1 (0.61) | SIGMAR1DRD2MEN1KMT2AKDM4E | |
| SCHEMBL5475896 | 0.87 | SIGMAR1 (0.58) | SIGMAR1MEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL13624854 | 0.83 | SIGMAR1 (0.71) | SIGMAR1DRD2KDM4EALDH1A1DRD4 | |
| SCHEMBL2178312 | 0.83 | SIGMAR1 (0.54) | SIGMAR1DRD2FAAH | |
| SCHEMBL5480249 | 0.82 | MEN1 (0.61) | SIGMAR1MEN1KMT2ALMNAFAAH | |
| SCHEMBL5490036 | 0.81 | MEN1 (0.55) | SIGMAR1DRD2MEN1KMT2AKDM4E | |
| SCHEMBL5477755 | 0.79 | FAAH (0.57) | SIGMAR1DRD2MEN1KMT2AFAAH | |
| SCHEMBL18672550 | 0.78 | SIGMAR1 (1.00) | SIGMAR1 | |
| SCHEMBL2931334 | 0.78 | SIGMAR1 (0.74) | SIGMAR1MEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL27564901 | 0.77 | SIGMAR1 (0.73) | SIGMAR1MEN1KMT2AKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1720848-B1 | DERIVATIVES OF ALKYLPIPERAZINE- AND ALKYLHOMOPIPERAZINE- CARBOXYLATES, PREPARATION METHOD THEREOF AND USE OF SAME AS FAAH ENZYME INHIBITORS | SANOFI AVENTIS (FR) | 2007-12-05 | — | — | EP | claimed |
| EP-1720848-B1 | DERIVATIVES OF ALKYLPIPERAZINE- AND ALKYLHOMOPIPERAZINE- CARBOXYLATES, PREPARATION METHOD THEREOF AND USE OF SAME AS FAAH ENZYME INHIBITORS | SANOFI AVENTIS (FR) | 2007-12-05 | — | — | EP | disclosed |