SCHEMBL5487643

SCHEMBL5487643

NCCCNc1c2c(nc3ccccc13)CCCC2

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
ACHE P22303 6/20 0.90
BCHE P06276 1/20 0.82

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5485655 0.96 ACHE (0.97) ACHEBCHE
SCHEMBL5489233 0.95 ACHE (1.00) ACHEBCHE
SCHEMBL1537859 0.95 ACHE (1.00) ACHEBCHE
SCHEMBL5945380 0.95 ACHE (1.00) ACHEBCHE
SCHEMBL5486217 0.95 ACHE (1.00) ACHEBCHE
SCHEMBL5945371 0.95 ACHE (1.00) ACHEBCHE
SCHEMBL19965901 0.94 ACHE (0.80) ACHEBCHE
SCHEMBL5492091 0.92 ACHE (0.81) ACHEBCHE
SCHEMBL24000133 0.92 BCHE (0.97) ACHEBCHE
SCHEMBL13480729 0.92 BCHE (0.92) ACHEBCHE

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-122036607-A Central targeting type tacrine conjugate based on transporter and preparation method and application thereof 中国药科大学 2026-05-15 CN disclosed
CN-110551067-B Multi-target tacrine derivative and preparation method and application thereof 山东大学 2020-09-08 CN disclosed
CN-110551067-A Multi-target tacrine derivative and preparation method and application thereof UNIV SHANDONG 2019-12-10 CN disclosed
CN-104244902-A Sample collection devices with blood stabilizing agents BECTON DICKINSON CO 2014-12-24 CN disclosed
CN-102391180-B Sulfydryl-containing tacrine derivative and preparation method and application thereof UNIV HUAZHONG SCIENCE TECH 2014-04-09 CN disclosed
US-20070299093-A1 Organic Compounds Useful for the Treatment of Alzheimer's Disease, Their Use and Method of Preparation Alma Mater Studiorum-Universitá Di Bologna (IT) 2007-12-27 US disclosed
US-7307083-B2 Tetrahydro-acridine and dithiolane derivatives ALMA MATER STUDIORUM-UNIVERSITA'DI BOLOGNA (IT) 2007-12-11 US disclosed
US-20070219241-A1 Organic Compounds Useful For The Treatment Of Alzheimer's Disease, Their Use And Method Of Preparation ALMA MATER STUDIORUM-UNIVERSITA'DI BOLOGNA (IT) 2007-09-20 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070219241-A1 Organic Compounds Useful For The Treatment Of Alzheimer's Disease, Their Use And Method Of Preparation OTC, PSEN2, PSEN1 ACHE 5/4885BCHE 7/4885
US-20070299093-A1 Organic Compounds Useful for the Treatment of Alzheimer's Disease, Their Use and Method of Preparation OTC, PSEN2, PSEN1 ACHE 5/4885BCHE 7/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.