SCHEMBL5487782

SCHEMBL5487782

Cc1ncc(NC(=O)c2cc(N3CCOCC3)cc(C(F)(F)F)c2)cc1C(N)=O

nearest known ligand 0.57

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
RAF1 P04049 18/20 0.57
BRAF P15056 18/20 0.57
CSF1R P07333 1/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4411276 0.83 RAF1 (0.53) RAF1BRAFCSF1R
SCHEMBL5490015 0.83 RAF1 (0.52) RAF1BRAFCSF1R
SCHEMBL5485734 0.81 RAF1 (0.51) RAF1BRAFCSF1R
SCHEMBL4417256 0.81 RAF1 (0.52) RAF1BRAFCSF1R
SCHEMBL4551612 0.80 RAF1 (0.52) RAF1BRAFCSF1R
SCHEMBL4409370 0.79 RAF1 (0.51) RAF1BRAFCSF1R
SCHEMBL5490044 0.79 MAPK14 (0.74) RAF1BRAFCSF1R
SCHEMBL5484353 0.79 RAF1 (0.48) RAF1BRAFCSF1R
SCHEMBL5487784 0.78 CSF1R (0.55) RAF1BRAFCSF1R
SCHEMBL5484352 0.78 CSF1R (0.50) RAF1BRAFCSF1R

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2007056016-A2 BISAMIDE CYTOKINE INHIBITORS KEMIA, INC. (US) 2007-05-18 WO disclosed