Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | SIRT6 | Q8N6T7 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 6/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13292851 | 0.80 | KMT2A (0.50) | MEN1KMT2ASIRT6MAPTALDH1A1 | |
| SCHEMBL6714741 | 0.79 | ALDH1A1 (0.53) | MEN1KMT2ASIRT6MAPTALDH1A1 | |
| SCHEMBL15514037 | 0.77 | MEN1 (0.47) | MEN1KMT2ASIRT6MAPTALDH1A1 | |
| SCHEMBL6605777 | 0.74 | ALDH1A1 (0.48) | MEN1KMT2AMAPTALDH1A1LMNA | |
| SCHEMBL16297415 | 0.74 | MAPT (0.52) | MEN1KMT2AMAPTALDH1A1LMNA | |
| SCHEMBL28949645 | 0.70 | MEN1 (0.43) | MEN1KMT2ASIRT6MAPTALDH1A1 | |
| Morpholine SCHEMBL27719 | 0.70 | SIRT6 (0.47) | MEN1KMT2ASIRT6MAPTALDH1A1 | |
| SCHEMBL16206949 | 0.69 | SIRT6 (0.57) | MEN1KMT2ASIRT6MAPTALDH1A1 | |
| SCHEMBL27972080 | 0.69 | MAPT (0.70) | MEN1KMT2ASIRT6MAPTALDH1A1 | |
| SCHEMBL6095682 | 0.69 | MAPT (0.47) | MEN1KMT2ASIRT6MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1740576-A1 | NOVEL PIPERIDINE SUBSTITUTED DIAMINOTHIAZOLES | F. Hoffman-la Roche AG (CH) | 2007-01-10 | — | — | EP | disclosed |
| WO-2005103034-A1 | NOVEL PIPERIDINE SUBSTITUTED DIAMINOTHIAZOLES | F. HOFFMAN-LA ROCHE AG (CH) | 2005-11-03 | — | — | WO | disclosed |