Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | ST6GAL1 | P15907 | 3/20 | 0.33 |
| ▸ | RNASE1 | P07998 | 1/20 | 0.33 |
| ▸ | CACNA1F | O60840 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | ALB | P02768 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | CACNA1D | Q01668 | 2/20 | 0.33 |
| ▸ | CACNA1S | Q13698 | 2/20 | 0.33 |
| ▸ | CACNA1C | Q13936 | 2/20 | 0.33 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.33 |
| ▸ | POLG | P54098 | 2/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | P2RY2 | P41231 | 1/20 | 0.32 |
| ▸ | P2RY4 | P51582 | 1/20 | 0.32 |
| ▸ | P2RY6 | Q15077 | 1/20 | 0.32 |
| ▸ | PPM1B | O75688 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8517853 | 0.88 | LMNA (0.40) | POLBCACNA1FLMNAALBMAPT | |
| SCHEMBL17749433 | 0.85 | ST6GAL1 (0.42) | ALDH1A1ST6GAL1LMNAHTT | |
| SCHEMBL15301518 | 0.84 | TYMP (0.35) | POLB | |
| SCHEMBL16131335 | 0.84 | TYMP (0.35) | POLB | |
| SCHEMBL21620269 | 0.83 | POLB (0.50) | POLBP2RY6 | |
| SCHEMBL9913496 | 0.82 | POLB (0.54) | POLBRNASE1P2RY2P2RY4P2RY6 | |
| SCHEMBL2365610 | 0.82 | POLG (0.38) | POLBCACNA1FLMNAALBMAPT | |
| SCHEMBL8658428 | 0.81 | POLB (0.49) | POLBP2RY2P2RY4P2RY6 | |
| SCHEMBL2056493 | 0.80 | — | — | |
| SCHEMBL5396749 | 0.80 | POLB (0.31) | POLBST6GAL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1496943-A4 | OLIGOMERIC COMPOUNDS HAVING MODIFIED PHOSPHATE GROUPS | ISIS PHARMACEUTICALS INC (US) | 2007-05-23 | — | — | EP | disclosed |
| EP-1496943-A2 | OLIGOMERIC COMPOUNDS HAVING MODIFIED PHOSPHATE GROUPS | ISIS PHARMACEUTICALS, INC. (US) | 2005-01-19 | — | — | EP | disclosed |
| WO-2003087115-A2 | OLIGOMERIC COMPOUNDS HAVING MODIFIED PHOSPHATE GROUPS | ISIS PHARMACEUTICALS, INC. (US) | 2003-10-23 | — | — | WO | disclosed |