Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.47 |
| ▸ | MAPT | P10636 | 7/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.42 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.42 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.42 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | CXCR5 | P32302 | 1/20 | 0.39 |
| ▸ | APLNR | P35414 | 1/20 | 0.39 |
| ▸ | CCR6 | P51684 | 1/20 | 0.39 |
| ▸ | GFER | P55789 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL397421 | 0.90 | MAPT (0.49) | ALDH1A1MAPTKMT2AMEN1RAB9A | |
| Formamide SCHEMBL28333185 | 0.86 | SLC2A1 (0.46) | ALDH1A1MAPTKMT2AMEN1RAB9A | |
| SCHEMBL5371 | 0.81 | CHRNA7 (0.44) | ALDH1A1MAPTKMT2AMEN1RAB9A | |
| Ammonia Solution, Strong SCHEMBL7429890 | 0.79 | ADRA2A (0.45) | ALDH1A1MAPTKMT2AMEN1RAB9A | |
| SCHEMBL28062195 | 0.77 | GAA (0.45) | ALDH1A1MAPTKMT2AMEN1RAB9A | |
| SCHEMBL19089741 | 0.77 | CYP1A2 (0.49) | ALDH1A1MAPTKMT2AMEN1RAB9A | |
| SCHEMBL4434207 | 0.76 | ALDH1A1 (0.52) | ALDH1A1MAPTKMT2AMEN1RAB9A | |
| SCHEMBL8466648 | 0.76 | ALDH1A1 (0.52) | ALDH1A1MAPTKMT2AMEN1ADRA2A | |
| SCHEMBL18078274 | 0.74 | MAPT (0.54) | ALDH1A1MAPTKMT2AMEN1RAB9A | |
| SCHEMBL3973866 | 0.73 | ADRA2A (0.46) | ALDH1A1MAPTKMT2AMEN1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1773816-A2 | MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS | Vertex Pharmaceuticals Incorporated (US) | 2007-04-18 | — | — | EP | disclosed |
| WO-2006002421-A2 | MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2006-01-05 | — | — | WO | disclosed |