Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 2/20 | 0.46 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.40 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.39 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | FBP1 | P09467 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 2/20 | 0.35 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.34 |
| ▸ | TNKS | O95271 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7672337 | 0.78 | ABCG2 (0.51) | MCL1AKR1C3ABCG2AKR1C1MEN1 | |
| SCHEMBL10436436 | 0.76 | MCL1 (0.47) | MCL1AKR1C3AKR1C1MEN1KMT2A | |
| SCHEMBL7149424 | 0.75 | MCL1 (0.46) | MCL1AKR1C3ABCG2AKR1C1MEN1 | |
| SCHEMBL7149422 | 0.75 | MCL1 (0.46) | MCL1AKR1C3ABCG2AKR1C1MEN1 | |
| SCHEMBL5504206 | 0.74 | MEN1 (0.62) | MCL1AKR1C3MEN1KMT2AALDH1A1 | |
| SCHEMBL5504208 | 0.74 | MEN1 (0.62) | MCL1AKR1C3MEN1KMT2AALDH1A1 | |
| SCHEMBL20596721 | 0.74 | MCL1 (0.45) | MCL1AKR1C3ABCG2AKR1C1MEN1 | |
| SCHEMBL10697896 | 0.70 | MCL1 (0.41) | MCL1AKR1C3ABCG2AKR1C1MEN1 | |
| SCHEMBL1259438 | 0.70 | MCL1 (0.57) | MCL1AKR1C3AKR1C1MEN1KMT2A | |
| SCHEMBL1628729 | 0.70 | MCL1 (0.57) | MCL1AKR1C3AKR1C1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070010428-A1 | Inhibitors of signal transduction and activator of transcription 3 | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM | 2007-01-11 | — | — | US | disclosed |