Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Triparanol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EBP | Q15125 | 4/20 | 0.86 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.86 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 3/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | LTA4H | P09960 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | AGER | Q15109 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.39 |
| ▸ | ESR1 | P03372 | 2/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Triparanol SCHEMBL133384 | 0.93 | EBP (1.00) | EBPSIGMAR1KMT2AMEN1NPSR1 | |
| SCHEMBL4310502 | 0.83 | EBP (0.81) | EBPSIGMAR1KMT2AMEN1NPSR1 | |
| SCHEMBL2711651 | 0.83 | EBP (0.73) | EBPSIGMAR1KMT2AMEN1NPSR1 | |
| SCHEMBL7753432 | 0.82 | SIGMAR1 (0.79) | EBPSIGMAR1KMT2AMEN1NPSR1 | |
| SCHEMBL10878286 | 0.78 | EBP (0.72) | EBPSIGMAR1KMT2AMEN1NPSR1 | |
| SCHEMBL16910242 | 0.76 | SIGMAR1 (0.69) | EBPSIGMAR1KMT2AMEN1NPSR1 | |
| SCHEMBL330094 | 0.74 | SIGMAR1 (0.67) | EBPSIGMAR1KMT2AMEN1NPSR1 | |
| SCHEMBL8707721 | 0.74 | EBP (0.60) | EBPSIGMAR1KMT2AMEN1NPSR1 | |
| SCHEMBL10358944 | 0.72 | EBP (0.62) | EBPSIGMAR1KMT2AMEN1NPSR1 | |
| SCHEMBL10878998 | 0.72 | EBP (0.63) | EBPSIGMAR1KMT2AMEN1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007062198-A1 | METHODS TO ACCELERATE THE ISOLATION OF NOVEL CELL STRAINS FROM PLURIPOTENT STEM CELLS AND CELLS OBTAINED THEREBY | ADVANCED CELL TECHNOLOGY, INC. (US) | 2007-05-31 | — | — | WO | disclosed |