SCHEMBL5488501

SCHEMBL5488501

Clc1cc(Cl)c(C[Si](Cl)(Cl)Cl)cc1Cl

nearest known ligand 0.35

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
MAPK1 P28482 1/20 0.35
AHR P35869 1/20 0.35
HPGD P15428 1/20 0.32
TSHR P16473 1/20 0.32
HSD17B10 Q99714 1/20 0.32
CYP3A4 P08684 1/20 0.30
IDO1 P14902 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5485036 0.81 CD44 (0.38) CYP3A4
SCHEMBL7953262 0.71 AHR (0.42) MAPK1AHRHPGDTSHRHSD17B10
SCHEMBL5490607 0.70
SCHEMBL5484887 0.70 KMT2A (0.37) MAPK1HPGDTSHRCYP3A4IDO1
SCHEMBL5490748 0.70
SCHEMBL11779597 0.69 AHR (0.40) MAPK1AHRHPGDTSHRHSD17B10
SCHEMBL17552704 0.67 MAPK1 (0.38) MAPK1AHRHPGDTSHRHSD17B10
SCHEMBL9396186 0.67 MAPK1 (0.38) MAPK1AHRHPGDTSHRHSD17B10
SCHEMBL900658 0.67 MAPK1 (0.38) MAPK1AHRHPGDTSHRHSD17B10
SCHEMBL11219358 0.67 GRIN2D (0.52) MAPK1AHRHPGDTSHRHSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7291747-B2 Silicon compounds and process for preparation thereof CHISSO CORPORATION (JP) 2007-11-06 US disclosed
US-20040143081-A1 Novel silicon compounds and process for preparation thereof JNC CORPORATION (JP) 2004-07-22 US disclosed