Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | TRPV1 | Q8NER1 | 4/20 | 0.51 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.51 |
| ▸ | PDE4A | P27815 | 3/20 | 0.50 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.50 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.50 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.50 |
| ▸ | PDE5A | O76074 | 2/20 | 0.50 |
| ▸ | PDE1A | P54750 | 2/20 | 0.50 |
| ▸ | PDE1B | Q01064 | 2/20 | 0.50 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.50 |
| ▸ | PDE1C | Q14123 | 2/20 | 0.50 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5474860 | 0.90 | HTT (0.53) | ALDH1A1KDM4ELMNATSHRMAPK1 | |
| SCHEMBL5470970 | 0.80 | TRPV1 (0.53) | TRPV1 | |
| SCHEMBL28781461 | 0.74 | HDAC6 (0.51) | ALDH1A1LMNATSHRPDE4APDE4B | |
| SCHEMBL5489770 | 0.73 | PI4KA (0.52) | KDM4ELMNAHTTHSD17B10TRPV1 | |
| SCHEMBL4202709 | 0.72 | TRPV1 (0.66) | TRPV1 | |
| SCHEMBL11813045 | 0.72 | ADORA2A (0.70) | LMNAHPGDSMN1; SMN2 | |
| SCHEMBL28146184 | 0.72 | HTT (0.57) | LMNATSHRHTTADORA3PDE4A | |
| SCHEMBL14431704 | 0.72 | CCNB2 (0.49) | ALDH1A1KDM4ELMNATSHRHTT | |
| SCHEMBL4148677 | 0.72 | TRPV1 (0.54) | TRPV1 | |
| SCHEMBL5451886 | 0.70 | HDAC6 (0.63) | HDAC1HDAC6NR3C1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070197559-A1 | Aryl substituted purine analogues | NEUROGEN CORPORATION | 2007-08-23 | — | — | US | disclosed |
| US-20070197559-A1 | Aryl substituted purine analogues | NEUROGEN CORPORATION | 2007-08-23 | — | — | US | disclosed |
| US-20070197559-A1 | Aryl substituted purine analogues | NEUROGEN CORPORATION | 2007-08-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070197559-A1 | Aryl substituted purine analogues | ADORA2A, GART, P2RX7 | ALDH1A1 569/4885KDM4E 3890/4885LMNA 2521/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.