Known targets — ChEMBL curated mechanism
GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQ
The experimentally established mechanism targets of Quercetin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 11/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 11/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 8/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 8/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 8/20 | 0.58 |
| ▸ | MAPT | P10636 | 8/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 7/20 | 0.58 |
| ▸ | RECQL | P46063 | 7/20 | 0.58 |
| ▸ | CYP1A1 | P04798 | 7/20 | 0.58 |
| ▸ | CYP1B1 | Q16678 | 7/20 | 0.58 |
| ▸ | ALOX15 | P16050 | 6/20 | 0.58 |
| ▸ | XDH | P47989 | 6/20 | 0.58 |
| ▸ | FTO | Q9C0B1 | 6/20 | 0.58 |
| ▸ | TP53 | P04637 | 5/20 | 0.58 |
| ▸ | LMNA | P02545 | 5/20 | 0.58 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 5/20 | 0.58 |
| ▸ | POLH | Q9Y253 | 5/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Quercetin SCHEMBL111510 | 0.78 | MEN1 (0.76) | MEN1KMT2ACYP3A4CYP1A2KDM4E | |
| Quercetin SCHEMBL4173190 | 0.77 | MEN1 (0.87) | MEN1KMT2ACYP3A4CYP1A2KDM4E | |
| Quercetin SCHEMBL3958393 | 0.77 | MEN1 (0.87) | MEN1KMT2ACYP3A4CYP1A2KDM4E | |
| Quercetin SCHEMBL27746111 | 0.76 | MEN1 (0.94) | MEN1KMT2ACYP3A4CYP1A2KDM4E | |
| Quercetin SCHEMBL29353785 | 0.76 | MEN1 (1.00) | MEN1KMT2ACYP3A4CYP1A2KDM4E | |
| Quercetin SCHEMBL29723041 | 0.76 | MEN1 (1.00) | MEN1KMT2ACYP3A4CYP1A2KDM4E | |
| Quercetin SCHEMBL31507620 | 0.76 | MEN1 (1.00) | MEN1KMT2ACYP3A4CYP1A2KDM4E | |
| Quercetin SCHEMBL19723 | 0.76 | MEN1 (1.00) | MEN1KMT2ACYP3A4CYP1A2KDM4E | |
| Quercetin SCHEMBL29351036 | 0.76 | MEN1 (1.00) | MEN1KMT2ACYP3A4CYP1A2KDM4E | |
| Quercetin SCHEMBL17629824 | 0.76 | MEN1 (1.00) | MEN1KMT2ACYP3A4CYP1A2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007062198-A1 | METHODS TO ACCELERATE THE ISOLATION OF NOVEL CELL STRAINS FROM PLURIPOTENT STEM CELLS AND CELLS OBTAINED THEREBY | ADVANCED CELL TECHNOLOGY, INC. (US) | 2007-05-31 | — | — | WO | disclosed |