Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCAT2 | O15382 | 1/20 | 0.51 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.46 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.45 |
| ▸ | FEN1 | P39748 | 1/20 | 0.45 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.43 |
| ▸ | CTSA | P10619 | 2/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.41 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.40 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.40 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.40 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.40 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.39 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.39 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.38 |
| ▸ | PLA2G10 | O15496 | 2/20 | 0.38 |
| ▸ | PLA2G2A | P14555 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27758304 | 0.83 | BCAT2 (0.59) | BCAT2CHEK1ALOX5APFEN1CTSA | |
| SCHEMBL27707954 | 0.77 | BCAT2 (0.56) | BCAT2CHEK1ALOX5APFEN1CTSA | |
| SCHEMBL5724410 | 0.77 | BCAT2 (0.56) | BCAT2CHEK1ALOX5APFEN1CTSA | |
| SCHEMBL2563193 | 0.76 | BCAT2 (0.65) | BCAT2CHEK1ALOX5APFEN1IRAK4 | |
| SCHEMBL29493488 | 0.76 | BCAT2 (0.53) | BCAT2IRAK4KEAP1NFE2L2HSP90AA1 | |
| SCHEMBL12543763 | 0.76 | BCAT2 (0.59) | BCAT2CHEK1ALOX5APFEN1IRAK4 | |
| SCHEMBL5878337 | 0.75 | BCAT2 (0.87) | BCAT2CHEK1ALOX5APFEN1SLC6A4 | |
| SCHEMBL31621279 | 0.74 | SLC6A2 (0.64) | BCAT2CHEK1ALOX5APFEN1SLC6A2 | |
| SCHEMBL31621280 | 0.74 | SLC6A2 (0.64) | BCAT2CHEK1ALOX5APFEN1SLC6A2 | |
| SCHEMBL25139064 | 0.74 | BCAT2 (0.49) | BCAT2CHEK1ALOX5APFEN1IRAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1836174-A2 | ARYL NITROGEN-CONTAINING BICYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS | AMGEN INC. (US) | 2007-09-26 | — | — | EP | claimed |
| WO-2006039718-A2 | ARYL NITROGEN-CONTAINING BICYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS | AMGEN INC (US) | 2006-04-13 | — | — | WO | claimed |
| WO-2016004272-A1 | INHIBITORS OF BRUTON'S TYROSINE KINASE | PHARMACYCLICS LLC (US) | 2016-01-07 | — | — | WO | disclosed |