Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCAT2 | O15382 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.49 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.49 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.45 |
| ▸ | FEN1 | P39748 | 1/20 | 0.45 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.43 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.43 |
| ▸ | APP | P05067 | 1/20 | 0.43 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.41 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.41 |
| ▸ | CTSA | P10619 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27758304 | 0.87 | BCAT2 (0.59) | BCAT2KDM4EALDH1A1MAPTHPGD | |
| SCHEMBL27707954 | 0.84 | BCAT2 (0.56) | BCAT2MAPTTSHRCHEK1MCL1 | |
| SCHEMBL19512829 | 0.81 | SLC6A3 (0.64) | KDM4EALDH1A1MAPTTSHRHSD17B10 | |
| SCHEMBL5724135 | 0.80 | PARP1 (0.56) | BCAT2KDM4EALDH1A1MAPTHPGD | |
| SCHEMBL5878337 | 0.78 | BCAT2 (0.87) | BCAT2KDM4EALDH1A1MAPTHPGD | |
| SCHEMBL17157028 | 0.78 | ALDH1A1 (0.52) | BCAT2ALDH1A1MAPTHPGDTSHR | |
| SCHEMBL6004326 | 0.78 | BCAT2 (0.71) | BCAT2KDM4EALDH1A1MAPTHPGD | |
| SCHEMBL28077145 | 0.77 | ALOX5AP (0.58) | BCAT2KDM4EALDH1A1MAPTHPGD | |
| SCHEMBL5490427 | 0.77 | BCAT2 (0.51) | BCAT2CHEK1MCL1ALOX5APFEN1 | |
| SCHEMBL1007616 | 0.77 | MCL1 (0.59) | KDM4EALDH1A1MAPTHPGDTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1633715-A1 | 2-(6-AMINO-PYRIDIN-3-YL)-2-HYDROXYETHYLAMINE DERIVATIVES AS BETA 2-ADRENOCEPTORS AGONISTS | Pfizer Limited (GB) | 2006-03-15 | — | — | EP | disclosed |
| WO-2004108676-A1 | 2-(6-AMINO-PYRIDIN-3-YL)-2-HYDROXYETHYLAMINE DERIVATIVES AS BETA 2-ADRENOCEPTORS AGONISTS | PFIZER LIMITED (GB) | 2004-12-16 | — | — | WO | disclosed |