Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.34 |
| ▸ | NOS3 | P29474 | 1/20 | 0.34 |
| ▸ | NOS1 | P29475 | 1/20 | 0.34 |
| ▸ | NOS2 | P35228 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.34 |
| ▸ | GRM5 | P41594 | 1/20 | 0.33 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | APOBEC3G | Q9HC16 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.32 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.32 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.32 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29876001 | 0.78 | L3MBTL1 (0.39) | L3MBTL1NOS3NOS1NOS2NPC1 | |
| SCHEMBL15413736 | 0.78 | TRIM24 (0.38) | L3MBTL1SLC22A12KDM4EHSD17B10AOC3 | |
| SCHEMBL18352991 | 0.78 | LMNA (0.37) | L3MBTL1GRM5SLC22A12KDM4EHSD17B10 | |
| SCHEMBL3074012 | 0.78 | NOS3 (0.47) | NOS3NOS1NOS2NPC1HSP90AA1 | |
| SCHEMBL5644357 | 0.76 | — | — | |
| SCHEMBL27791995 | 0.75 | GRM5 (0.37) | L3MBTL1NPC1GRM5SLC22A12KDM4E | |
| SCHEMBL15961557 | 0.75 | KDM4E (0.49) | L3MBTL1NPC1HSP90AA1KDM4EGAA | |
| SCHEMBL18353016 | 0.75 | PTPN11 (0.38) | — | |
| SCHEMBL18526835 | 0.74 | HTT (0.57) | L3MBTL1NPC1HSP90AA1KDM4EMAPT | |
| SCHEMBL22766464 | 0.74 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1392653-B1 | A SHORT SYNTHESIS OF PYRIDINE-BASED PHARMACEUTICAL INTERMEDIATES WITH SULFUR-CONTAINING GROUPS AT THE 2- AND 3-POSITIONS | UNIV NORTH CAROLINA STATE (US) | 2007-08-15 | — | — | EP | disclosed |
| US-6987189-B2 | Short synthesis of pyridine-based pharmaceutical intermediates | NORTH CAROLINA STATE UNIVERSITY (US) | 2006-01-17 | — | — | US | disclosed |
| US-20050065347-A1 | Short synthesis of pyridine-based pharmaceutical intermediates | COMINS DANIEL L (US) | 2005-03-24 | — | — | US | disclosed |
| US-6855825-B2 | Short synthesis of pyridine-based pharmaceutical intermediates | NORTH CAROLINA STATE UNIVERSITY (US) | 2005-02-15 | — | — | US | disclosed |
| CN-1533379-A | Small synthesis of pyridine-based pharmaceutical intermediates containing sulfur in the 2-and 3-positions | �Ϻ���ͨ��ѧ | 2004-09-29 | — | — | CN | disclosed |
| US-20040138463-A1 | Short synthesis of pyridine-based pharmaceutical intermediates | COMINS DANIEL L (US) | 2004-07-15 | — | — | US | disclosed |
| US-6706884-B2 | REACTING 2-METHYL-3-(TERT-BUTYLTHIO)PYRIDINE DERIVATIVE WITH AMINOALKYL DISULFIDE DERIVATIVE; SULFIDING IN STRONG AMIDE BASE | NORTH CAROLINA STATE UNIVERSITY | 2004-03-16 | — | — | US | disclosed |
| EP-1392653-A1 | A SHORT SYNTHESIS OF PYRIDINE-BASED PHARMACEUTICAL INTERMEDIATES WITH SULFUR-CONTAINING GROUPS AT THE 2- AND 3-POSITIONS | North Carolina State University (US) | 2004-03-03 | — | — | EP | disclosed |
| US-20030166941-A1 | Short synthesis of pyridine-based pharmaceutical intermediates | COMINS DANIEL L (US) | 2003-09-04 | — | — | US | disclosed |
| US-6534656-B2 | Intermediates in manufacture of antibiotic compounds | NORTH CAROLINA STATE UNIVERSITY | 2003-03-18 | — | — | US | disclosed |
| US-20020193606-A1 | Short synthesis of pyridine-based pharmaceutical intermediates | NORTH CAROLINA STATE UNIVERSITY | 2002-12-19 | — | — | US | disclosed |
| WO-2002096878-A1 | A SHORT SYNTHESIS OF PYRIDINE-BASED PHARMACEUTICAL INTERMEDIATES WITH SULFUR-CONTAINING GROUPS AT THE 2- AND 3-POSITIONS | NORTH CAROLINA STATE UNIVERSITY (US) | 2002-12-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030166941-A1 | Short synthesis of pyridine-based pharmaceutical intermediates | CYP2B6, CYP2D6, CYP2A6 | L3MBTL1 4339/4885NOS3 3506/4885NOS1 4290/4885 |
| US-20040138463-A1 | Short synthesis of pyridine-based pharmaceutical intermediates | CYP2B6, CYP2D6, CYP2A6 | L3MBTL1 4339/4885NOS3 3506/4885NOS1 4290/4885 |
| US-20020193606-A1 | Short synthesis of pyridine-based pharmaceutical intermediates | CYP2B6, CYP2D6, CYP2A6 | L3MBTL1 4339/4885NOS3 3506/4885NOS1 4290/4885 |
| US-20050065347-A1 | Short synthesis of pyridine-based pharmaceutical intermediates | CYP2B6, CYP2D6, CYP2A6 | L3MBTL1 4314/4885NOS3 2378/4885NOS1 3657/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.