SCHEMBL5491149

SCHEMBL5491149

Cc1cccc(C(C)[Si](Cl)(Cl)Cl)c1

nearest known ligand 0.44

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
ACHE P22303 5/20 0.44
AOC3 Q16853 1/20 0.41
ALDH1A1 P00352 3/20 0.41
ACP3 P15309 1/20 0.41
GAA P10253 1/20 0.41
L3MBTL1 Q9Y468 1/20 0.41
SOS1 Q07889 1/20 0.40
HPGD P15428 1/20 0.39
CYP19A1 P11511 2/20 0.37
MAPKAPK2 P49137 1/20 0.37
MAPK1 P28482 1/20 0.37
EPHX1 P07099 1/20 0.36
PFKFB3 Q16875 1/20 0.36
MAPT P10636 1/20 0.36
TSHR P16473 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17886087 0.81 ACHE (0.46) ACHEAOC3ALDH1A1ACP3GAA
Toluene SCHEMBL18394200 0.81 LMNA (0.48) ACHEAOC3ACP3TSHR
SCHEMBL5491029 0.79 AOC3 (0.44) AOC3ACP3
SCHEMBL8470837 0.76 ACHE (0.50) ACHEAOC3ALDH1A1ACP3GAA
SCHEMBL8750604 0.76 ACHE (0.50) ACHEAOC3ALDH1A1ACP3GAA
SCHEMBL7795647 0.75 TSHR (0.43) AOC3ALDH1A1TSHR
SCHEMBL208902 0.75 TSHR (0.43) AOC3ALDH1A1TSHR
SCHEMBL931982 0.75 ACHE (0.55) ACHEAOC3ALDH1A1ACP3GAA
SCHEMBL99347 0.75 ACHE (0.55) ACHEAOC3ALDH1A1ACP3GAA
SCHEMBL29352930 0.75 ACHE (0.55) ACHEAOC3ALDH1A1ACP3GAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7291747-B2 Silicon compounds and process for preparation thereof CHISSO CORPORATION (JP) 2007-11-06 US disclosed
US-20040143081-A1 Novel silicon compounds and process for preparation thereof JNC CORPORATION (JP) 2004-07-22 US disclosed