Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 1/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.47 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.45 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.44 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.43 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | CNR2 | P34972 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12544171 | 0.81 | NR1H3 (0.57) | CES2RXFP1LMNAOPRM1OPRL1 | |
| SCHEMBL4461612 | 0.81 | ATM (0.45) | RXFP1KCNK3NPSR1MEN1KMT2A | |
| SCHEMBL4526462 | 0.80 | HPGD (0.50) | CES2NPSR1KMT2AALDH1A1HTT | |
| SCHEMBL28020267 | 0.78 | CES2 (0.51) | CES2KCNK3LMNAOPRM1OPRL1 | |
| SCHEMBL18825315 | 0.77 | HTT (0.40) | CES2KCNK3LMNAOPRM1OPRL1 | |
| SCHEMBL17891690 | 0.76 | RXFP1 (0.43) | RXFP1LMNAMEN1KMT2AALDH1A1 | |
| SCHEMBL20401477 | 0.75 | HSD17B1 (0.48) | RXFP1HSD17B1HSD17B2HTTMAPT | |
| SCHEMBL11536412 | 0.74 | TP53 (0.42) | RXFP1KCNK3NPSR1LMNAMEN1 | |
| SCHEMBL323339 | 0.74 | CES2 (0.57) | CES2NPSR1LMNAOPRM1OPRL1 | |
| SCHEMBL17671165 | 0.72 | CES2 (0.44) | CES2RXFP1NPSR1LMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1836174-A2 | ARYL NITROGEN-CONTAINING BICYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS | AMGEN INC. (US) | 2007-09-26 | — | — | EP | claimed |
| WO-2006039718-A2 | ARYL NITROGEN-CONTAINING BICYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS | AMGEN INC (US) | 2006-04-13 | — | — | WO | claimed |