Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TERT | O14746 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 3/20 | 0.36 |
| ▸ | RAB9A | P51151 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.36 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.36 |
| ▸ | RAD52 | P43351 | 1/20 | 0.36 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.35 |
| ▸ | ATM | Q13315 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | TOP2A | P11388 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | MOK | Q9UQ07 | 1/20 | 0.34 |
| ▸ | NCF1 | P14598 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3290733 | 0.74 | POLB (0.51) | TERTNPC1RAB9AKMT2APOLB | |
| SCHEMBL9697536 | 0.72 | SMN1; SMN2 (0.44) | NPC1RAB9AKMT2AATMMEN1 | |
| Biscryptolepine SCHEMBL30192568 | 0.71 | TERT (0.54) | TERTNPC1RAB9AKMT2APOLB | |
| SCHEMBL21361394 | 0.70 | PRMT1 (0.41) | KMT2AATMMEN1KDM4EALDH1A1 | |
| SCHEMBL3298450 | 0.70 | KAT2B (0.44) | TERTNPC1RAB9AKMT2APOLB | |
| SCHEMBL3291144 | 0.70 | TERT (0.53) | TERTKMT2APOLBMEN1KDM4E | |
| SCHEMBL3291028 | 0.68 | TERT (0.51) | TERTNPC1RAB9AKMT2APOLB | |
| SCHEMBL8480481 | 0.68 | TERT (0.51) | TERTNPC1RAB9AKMT2APOLB | |
| SCHEMBL3292083 | 0.68 | RAD52 (0.47) | TERTNPC1RAB9AKMT2APOLB | |
| Hydrochloric Acid SCHEMBL8485102 | 0.67 | TERT (0.50) | TERTNPC1RAB9AKMT2APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2007511573-A | — | — | 2007-05-10 | — | — | JP | claimed |
| EP-1687304-A1 | SUBSTITUTED QUINOLINES FOR THE TREATMENT OF CANCER | Crystax Pharmaceuticals S.L. (ES) | 2006-08-09 | — | — | EP | claimed |
| WO-2005054236-A1 | SUBSTITUTED QUINOLINES FOR THE TREATMENT OF CANCER | CRYSTAX PHARMACEUTICALS S.L. (ES) | 2005-06-16 | — | — | WO | claimed |
| EP-1687304-A1 | SUBSTITUTED QUINOLINES FOR THE TREATMENT OF CANCER | Crystax Pharmaceuticals S.L. (ES) | 2006-08-09 | — | — | EP | disclosed |
| WO-2005054236-A1 | SUBSTITUTED QUINOLINES FOR THE TREATMENT OF CANCER | CRYSTAX PHARMACEUTICALS S.L. (ES) | 2005-06-16 | — | — | WO | disclosed |