Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.51 |
| ▸ | RAD52 | P43351 | 3/20 | 0.51 |
| ▸ | SLC2A1 | P11166 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.51 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.49 |
| ▸ | EIF4H | Q15056 | 1/20 | 0.49 |
| ▸ | TERT | O14746 | 2/20 | 0.48 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.48 |
| ▸ | NCF1 | P14598 | 2/20 | 0.48 |
| ▸ | TOP2A | P11388 | 1/20 | 0.48 |
| ▸ | TLR9 | Q9NR96 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.44 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.44 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3292083 | 0.83 | RAD52 (0.47) | POLBRAD52SLC2A1NPC1APOBEC3A | |
| SCHEMBL3298450 | 0.81 | KAT2B (0.44) | POLBRAD52SLC2A1NPC1APOBEC3A | |
| SCHEMBL3427601 | 0.76 | EGFR (0.43) | SLC2A1TERTALDH1A1 | |
| SCHEMBL3427605 | 0.76 | EGFR (0.43) | SLC2A1TERTALDH1A1 | |
| SCHEMBL3291426 | 0.75 | BRD4 (0.46) | NPC1RAB9AKMT2AHRH3GAA | |
| SCHEMBL3519650 | 0.74 | CACNA2D1 (0.40) | POLBRAD52SLC2A1NPC1APOBEC3A | |
| SCHEMBL5492192 | 0.74 | TERT (0.40) | POLBRAD52SLC2A1NPC1APOBEC3A | |
| Biscryptolepine SCHEMBL30192568 | 0.72 | TERT (0.54) | POLBNPC1RAB9AKMT2ATERT | |
| SCHEMBL14797501 | 0.72 | PDGFRB (0.61) | POLBNPC1RAB9AKMT2ATERT | |
| SCHEMBL3291144 | 0.70 | TERT (0.53) | POLBKMT2ATERTTOP2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100331355-A1 | Substituted Quinolines for the Treatment of Cancer | CRYSTAX PHARMACEUTICALS, S.L. (ES) | 2010-12-30 | — | — | US | disclosed |
| US-7728000-B2 | Substituted quinolines for the treatment of cancer | CRYSTAX PHARMACEUTICALS (ES) | 2010-06-01 | — | — | US | disclosed |
| US-20070105784-A1 | Substituted quinolines for the treatment of cancer | CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS (ES) | 2007-05-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070105784-A1 | Substituted quinolines for the treatment of cancer | TOP2B, NQO2, SNRPD2 | POLB 599/4885RAD52 224/4885SLC2A1 1392/4885 |
| US-20100331355-A1 | Substituted Quinolines for the Treatment of Cancer | TOP2B, TOP1, TOP2A | POLB 607/4885RAD52 198/4885SLC2A1 1045/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.