Known targets — ChEMBL curated mechanism
ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1HRH1HTR7IDH1IDH2IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 known ✓ | P35372 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | SLC13A5 | Q86YT5 | 2/20 | 0.34 |
| ▸ | DDB1 | Q16531 | 8/20 | 0.34 |
| ▸ | CRBN | Q96SW2 | 8/20 | 0.34 |
| ▸ | IKZF3 | Q9UKT9 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | PKLR | P30613 | 1/20 | 0.33 |
| ▸ | TNF | P01375 | 1/20 | 0.32 |
| ▸ | IL1B | P01584 | 1/20 | 0.32 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.32 |
| ▸ | IKZF1 | Q13422 | 1/20 | 0.32 |
| ▸ | CA12 | O43570 | 1/20 | 0.30 |
| ▸ | CA9 | Q16790 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | ATM | Q13315 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5023145 | 0.84 | KMT2A (0.33) | TSHRGAASLC13A5DDB1CRBN | |
| Citric Acid SCHEMBL3498933 | 0.74 | ALDH1A1 (0.50) | TSHRSLC13A5ALDH1A1CYP1A2KDM4E | |
| SCHEMBL845434 | 0.73 | CRBN (0.57) | TSHRDDB1CRBNIKZF3ALDH1A1 | |
| Thalidomide SCHEMBL30511827 | 0.73 | CRBN (0.67) | TSHRDDB1CRBNIKZF3ALDH1A1 | |
| SCHEMBL18263933 | 0.70 | CRBN (0.55) | TSHRDDB1CRBNIKZF3ALDH1A1 | |
| SCHEMBL3125601 | 0.70 | CRBN (0.55) | TSHRDDB1CRBNIKZF3ALDH1A1 | |
| SCHEMBL9988737 | 0.67 | DDB1 (0.64) | TSHRDDB1CRBNIKZF3ALDH1A1 | |
| SCHEMBL22845492 | 0.66 | DDB1 (0.53) | DDB1CRBN | |
| SCHEMBL2065573 | 0.66 | CRBN (0.65) | TSHRDDB1CRBNIKZF3ALDH1A1 | |
| SCHEMBL31013981 | 0.66 | CRBN (0.65) | TSHRDDB1CRBNIKZF3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007062198-A1 | METHODS TO ACCELERATE THE ISOLATION OF NOVEL CELL STRAINS FROM PLURIPOTENT STEM CELLS AND CELLS OBTAINED THEREBY | ADVANCED CELL TECHNOLOGY, INC. (US) | 2007-05-31 | — | — | WO | disclosed |