Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 2/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.63 |
| ▸ | LMNA | P02545 | 2/20 | 0.63 |
| ▸ | TSHR | P16473 | 5/20 | 0.62 |
| ▸ | HPGD | P15428 | 1/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.58 |
| ▸ | MAPT | P10636 | 4/20 | 0.58 |
| ▸ | NPC1 | O15118 | 4/20 | 0.58 |
| ▸ | RAB9A | P51151 | 4/20 | 0.58 |
| ▸ | PKM | P14618 | 3/20 | 0.58 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.58 |
| ▸ | NFKB2 | Q00653 | 3/20 | 0.58 |
| ▸ | RELA | Q04206 | 3/20 | 0.58 |
| ▸ | HTT | P42858 | 2/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.58 |
| ▸ | MEN1 | O00255 | 2/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.58 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10899996 | 0.84 | NOTUM (0.62) | NOTUMALDH1A1LMNATSHRHPGD | |
| SCHEMBL29611497 | 0.84 | NOTUM (0.62) | NOTUMALDH1A1LMNATSHRHPGD | |
| SCHEMBL789554 | 0.83 | ALDH1A1 (0.71) | NOTUMALDH1A1LMNATSHRHPGD | |
| SCHEMBL29449730 | 0.83 | ALDH1A1 (0.71) | NOTUMALDH1A1LMNATSHRHPGD | |
| Hydrochloric Acid SCHEMBL10741975 | 0.81 | ALDH1A1 (0.69) | NOTUMALDH1A1LMNATSHRHPGD | |
| SCHEMBL4780895 | 0.81 | KMT2A (0.83) | NOTUMALDH1A1LMNATSHRHPGD | |
| SCHEMBL4016843 | 0.81 | ALDH1A1 (0.66) | NOTUMALDH1A1LMNATSHRHPGD | |
| SCHEMBL4016837 | 0.81 | ALDH1A1 (0.66) | NOTUMALDH1A1LMNATSHRHPGD | |
| SCHEMBL5492978 | 0.81 | SMN1; SMN2 (0.79) | NOTUMALDH1A1LMNATSHRHPGD | |
| SCHEMBL29804966 | 0.81 | NOTUM (0.72) | NOTUMALDH1A1LMNATSHRHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458734-A4 | DERIVATIVES OF ISOINDIGO, INDIGO AND INDIRUBIN AND USE IN TREATING CANCER | NATROGEN THERAPEUTICS INC (US) | 2007-12-19 | — | — | EP | claimed |
| EP-1458734-A1 | DERIVATIVES OF ISOINDIGO, INDIGO AND INDIRUBIN AND USE IN TREATING CANCER | Natrogen Therapeutics, Inc. (US) | 2004-09-22 | — | — | EP | claimed |
| WO-2003051900-A1 | DERIVATIVES OF ISOINDIGO, INDIGO AND INDIRUBIN AND USE IN TREATING CANCER | NATROGEN THERAPEUTICS, INC. (US) | 2003-06-26 | — | — | WO | claimed |